L. Yin

Plaat1l1 controls feeding induced NAPE biosynthesis and contributes to energy balance regulation in zebrafish.

This study identifies plaat1l1 as a key enzyme for feeding-induced NAPE biosynthesis in zebrafish, showing its role in energy balance regulation and obesity prevention.

Targeted NAD+ Delivery for Intimal Hyperplasia and Re-endothelialization: A Novel Anti-restenotic Therapy Approach

This study demonstrates that targeted NAD+ delivery via nanocarriers reduces intimal hyperplasia and promotes endothelial regeneration in a rat model of restenosis.

ATM-Mediated Translocation of RanBPM Regulates DNA Damage Response by Stabilizing p21 in Non-Small Cell Lung Cancer Cells

The paper identifies a novel mechanism where RanBPM stabilizes p21 via deubiquitination, regulating DNA damage response in NSCLC cells.

The kinematics and aerodynamics of hinged wing of honeybees during takeoff

This study analyzes honeybee wing kinematics during takeoff, revealing key parameters and the role of hinged wings in thrust generation.

Hierarchical Clustering and Omics Analysis Revealed Massive Molecular Shifts in a Tree under Combined Hypoxia and Salinity

This study identifies molecular shifts in Dalbergia odorifera under combined hypoxia and salinity through transcriptomic and metabolic analysis.

Pancreatic islet α cell function and proliferation requires the arginine transporter SLC7A2

This study identifies SLC7A2 as essential for α cell proliferation and glucagon secretion, linking arginine transport to metabolic regulation and HbA1c variation.

ATP is a major determinant of phototrophic bacterial longevity in growth arrest.

This study shows that ATP depletion leads to cell death in Rhodopseudomonas palustris during growth arrest, while ATP-replete conditions allow long-term survival.

Transcription Factor Dynamics in Cross-Regulation of Plant Hormone Signaling Pathways

The paper constructs a cross-regulation network of plant hormone signaling pathways by analyzing transcription factor activity and dynamic regulatory models in Arabidopsis seedlings.

A method for rapid nanobody screening with no bias of the library diversity

This paper introduces a method for rapid nanobody screening that preserves library diversity without subcloning or amplification bias, producing functional nanobodies against DR5 and Pfu DNA polymerase.

Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues

This study shows that mitochondrial dysfunction triggers a retrograde signaling program that reduces cellular maturity in metabolic tissues, and blocking this signaling can restore cell identity and improve hyperglycemia.

An overlapped natural antisense lncRNA FCER1A-AS controls anaphylactic reaction by promoting FcϵRIα expression

This study identifies FCER1A-AS, an antisense lncRNA, as a regulator of FcϵRIα expression, which is critical for anaphylactic reactions.

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

This study shows that Omicron variant's spike protein has enhanced ACE2 binding and reduces neutralizing activity, but some broadly neutralizing antibodies remain effective.

Phosphorylation regulates arginine-rich RNA-binding protein solubility and oligomerization

This study shows phosphorylation prevents arginine-rich RNA-binding proteins from becoming insoluble and forming oligomers.

Cross-reactive TCR with alloreactivity for immunodominant HIV-1 epitope Gag TL9 with enhanced control of viral infection

The paper identifies a dual-reactive TCR that recognizes HIV-1 epitope Gag TL9 presented by both HLA B*81:01 and B*42:01, showing enhanced control of viral infection through structural and functional analysis.

Mechanism of the Switch from NO to H2O2 in Endothelium-Dependent Vasodilation in Diabetes

This study identifies an NO-to-H2O2 switch in diabetic coronary vasodilation mediated by miR-21, contributing to microvascular dysfunction.

Deep oncopanel sequencing reveals fixation time- and within block position-dependent quality degradation in FFPE processed samples

This study identifies FFPE processing errors in oncology panel sequencing by analyzing variants from technical artifacts in FFPE samples with varying fixation times and block positions.

Structure and dynamics of SARS-CoV-2 proofreading exoribonuclease ExoN

This study determines the structure of SARS-CoV-2 ExoN and its interaction with nsp10, revealing mechanisms of RNA substrate binding and exoribonuclease activity.

The intestinal microbiota-driven dopamine level influences social interaction and innate color preference in zebrafish larvae

This study shows that gut microbiota influence dopamine levels, which in turn affect social interaction and color preference in zebrafish larvae.

Immune-based mutation classification enables neoantigen prioritization and immune feature discovery in cancer immunotherapy

The paper classifies neoantigens based on immune interactions and improves their prioritization for cancer immunotherapy.

Unique Genotypic Features of HIV-1 C Gp41 Membrane Proximal External Region Variants during Pregnancy Relate to Mother-to-child Transmission via Breastfeeding

The paper analyzes HIV-1 subtype C gp41 variants in pregnant mothers to identify features linked to mother-to-child transmission via breastfeeding.

Social interaction influences innate color preference of zebrafish shoals

This study shows zebrafish shoals exhibit color preferences that are lost in individuals, suggesting social interaction influences innate color preference, possibly via the dopaminergic system.

Bacterial longevity requires protein synthesis and a stringent response

This study shows that protein synthesis and a stringent response are required for bacterial longevity during growth arrest in Rhodopseudomonas palustris.

Integrated Multi-omic Framework of the Plant Response to Jasmonic Acid

The paper develops an integrated multi-omic framework to study the plant response to jasmonic acid, identifying new regulatory components and crosstalk points with other signaling pathways.