Immunomodulatory effects of cytokine-induced expansion of cytotoxic lymphocytes in a mouse model of lupus-like disease
S. D. Reighard, D. Krishnamurthy, H. Cevik, D. E. Ohayon, A. Ali, H. Seelamneni, H. I. Brunner, S. N. Waggoner
This study shows that expanding cytotoxic lymphocytes with IL-2 and IL-15 worsens lupus-like disease in mice, likely due to CD8 T cell expansion rather than NK cells.
bioRxiv · Aug 10, 2020Immunology