Author

L. Kottyan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:proteomics· 4 Research Focus:cell type annotation· 3 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

M. T. Weirauch· 2 shared A. Ali· 1 shared A. Assa'ad· 1 shared A. Baatyrbek kyzy· 1 shared A. L. Devonshire· 1 shared A. Lynch· 1 shared A. M. Klingler· 1 shared A. T. Dwyer· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersImmunology

M. T. Weirauch

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The transcription factor Zeb2 drives differentiation of age-associated B cells

D. Dai, S. Gu, X. Han, H. Ding, Y. Jiang, X. Zhang, C. Yao, S. Hong, J. Zhang, Y. Shen, G. Hou, B. Qu, H. Zhou, Y. Qin, Y. He, , N. Shen

The paper identifies Zeb2 as a critical transcription factor driving age-associated B-cell differentiation and autoimmunity in humans and mice.

Science · Jan 26, 2024Peer-reviewedImmunology

Aryl Hydrocarbon Receptor Suppresses Eosinophilic Esophagitis Responses through OVOL1 and SPINK7

N. P. Azouz, A. M. Klingler, M. Rochman, M. Paul, J. M. Caldwell, M. Brusilovsky, A. T. Dwyer, X. P. Chen, D. Miller, A. Lynch, C. Forney, L. Kottyan, M. T. Weirauch, M. E. Rothenberg

This study identifies OVOL1 as a regulator of SPINK7 expression in eosinophilic esophagitis, showing AHR activation enhances SPINK7 and barrier function while IL-4 and IL-13 inhibit this pathway.

bioRxiv · May 17, 2023 · PreprintImmunology

B cell repertoire of children with atopic dermatitis exhibit altered IgE maturationassociated with allergic food sensitization

K. Gill, C. Moore, O. Nwogu, J. W. Kroner, W.-C. Chang, J. Burkle, S. J. Virolainen, M. L. Stevens, A. Baatyrbek kyzy, E. Miraldi, J. Biagini, A. L. Devonshire, L. Kottyan, J. T. Schwartz, A. Assa'ad, , K. M. Roskin

The paper examines IgE B cell repertoires in children with atopic dermatitis, finding altered IgE maturation linked to allergic food sensitization and pet ownership effects.

bioRxiv · Feb 1, 2023Immunology

Interleukin-33 promotes type 1 cytokine expression via p38 MAPK in human natural killer cells

D. E. Ohayon, A. Ali, P. C. Alarcon, D. Krishnamurthy, L. Kottyan, M. Borchers, S. N. Waggoner

This study shows IL-33 enhances IFN-gamma and TNF secretion in human NK cells through p38 MAPK activation when combined with IL-12.

bioRxiv · Dec 23, 2019 · PreprintImmunology