D. F. Hansen

Increasing the accuracy of exchange parameters reporting on slow dynamics by performing CEST experiments with high B1 fields

This paper improves the accuracy of exchange parameters in CEST experiments by using K instead of kex to guide B1 field selection, demonstrating better results in two FF domain mutants.

Characterising Aromatic Side Chains in Proteins through the Synergistic Development of NMR Experiments and Deep Neural Networks

This paper develops a deep neural network, FID-Net-2, combined with custom NMR experiments to accurately reconstruct high-resolution aromatic 1H-13C correlation spectra from uniformly 13C-labeled protein samples.

Solution State Methyl NMR Spectroscopy of Large Non-Deuterated Proteins Enabled by Deep Neural Networks

This paper uses deep neural networks to process methyl-TROSY NMR spectra of non-deuterated proteins, achieving results comparable to deuterated samples.

Small-molecule binding to an intrinsically disordered protein revealed by experimental NMR 19F transverse spin-relaxation

This study shows that 19F transverse relaxation rates from NMR can detect small-molecule binding to intrinsically disordered proteins, demonstrating 5-fluoroindole binds to HCV NS5A with a Kd of 260 ± 110 M.

Anatomy of unfolding: The site-specific fold stability of Yfh1 measured by 2D NMR

This study uses 2D NMR to analyze site-specific stability of Yfh1 during cold and heat denaturation, revealing differences between unfolding processes.