V. K. Shukla

Characterising Aromatic Side Chains in Proteins through the Synergistic Development of NMR Experiments and Deep Neural Networks

This paper develops a deep neural network, FID-Net-2, combined with custom NMR experiments to accurately reconstruct high-resolution aromatic 1H-13C correlation spectra from uniformly 13C-labeled protein samples.

Solution State Methyl NMR Spectroscopy of Large Non-Deuterated Proteins Enabled by Deep Neural Networks

This paper uses deep neural networks to process methyl-TROSY NMR spectra of non-deuterated proteins, achieving results comparable to deuterated samples.

Small-molecule binding to an intrinsically disordered protein revealed by experimental NMR 19F transverse spin-relaxation

This study shows that 19F transverse relaxation rates from NMR can detect small-molecule binding to intrinsically disordered proteins, demonstrating 5-fluoroindole binds to HCV NS5A with a Kd of 260 ± 110 M.

Implications of critical nodes-dependent unidirectional cross-talk between Plasmodium and Human SUMO

This study identifies critical residues in Plasmodium SUMO and Ubc9 that enable unidirectional cross-species interactions with human SUMOylation machinery, suggesting potential targets for antimalarial drugs.