Author

D. G. Diel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Immunology· 3 Pathology· 1 Zoology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:host-pathogen & immune response· 9 Organism:mouse· 4 Assay:bulk RNA-seq· 2 Organism:fungi (other)· 2 Organism:non-human primate· 2 Research Focus:ecology & biodiversity· 1 Organism:multiple species· 1

Frequent Co-Authors

L. C. Caserta· 7 shared M. Martins· 7 shared Y. Fang· 3 shared A. Conforti· 2 shared B. Viscount· 2 shared B. Wagner· 2 shared C. McCann· 2 shared C. Olmstead· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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Curved chords = mutual co-authorship

7 shared papersMicrobiology

L. C. Caserta

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

The SARS-CoV-2 Spike is a virulence determinant and plays a major role on the attenuated phenotype of Omicron virus in a feline model of infection

M. Martins, M. Nooruzzaman, J. L. Cunningham, C. Ye, L. C. Caserta, N. Jackson, L. Martinez-Sobrido, Y. Fang, D. G. Diel

This study shows the Omicron BA.1 Spike protein reduces SARS-CoV-2 virulence in a feline model by impairing viral spread and causing less severe disease.

bioRxiv · Oct 9, 2023Microbiology

A linear SARS-CoV-2 DNA vaccine candidate reduces virus shedding in ferrets

M. Martins, G. M. do Nascimento, A. Conforti, J. C. G. Noll, J. A. Impellizeri, E. Sanches, B. Wagner, L. Lione, E. Salvatori, E. Pinto, M. Compagnone, B. Viscount, J. Hayward, C. Shorrock, L. Aurisicchio, D. G. Diel

This study evaluates a linear SARS-CoV-2 DNA vaccine delivered via electroporation in ferrets, showing reduced virus shedding and immune responses.

bioRxiv · Sep 29, 2022 · PreprintImmunology

White-tailed deer (Odocoileus virginianus) may serve as a wildlife reservoir for nearly extinct SARS-CoV-2 variants of concern

L. C. Caserta, M. Martins, S. L. Butt, N. Hollingshead, L. M. Covaleda, M. Everts, K. Schuler, D. G. Diel

This study shows SARS-CoV-2 infects and circulates in white-tailed deer, with multiple variants co-circulating long after they disappeared from humans.

bioRxiv · Sep 2, 2022Microbiology

A linear DNA vaccine candidate encoding the SARS-CoV-2 Receptor Binding Domain elicits protective immunity in domestic cats

A. Conforti, E. Sanchez, E. Salvatori, L. Lione, M. Compagnone, E. Pinto, F. Palombo, Y. Sun, B. Viscount, J. Hayward, C. Shorrock, D. G. Diel, J. A. Impellizeri, L. Aurisicchio

This study evaluates a linear DNA vaccine in domestic cats, showing it is safe and induces immune responses against SARS-CoV-2.

bioRxiv · Jul 20, 2022 · PreprintImmunology

The Omicron variant BA.1.1 presents a lower pathogenicity than B.1 D614G and Delta variants in a feline model of SARS-CoV-2 infection

M. Martins, G. M. do Nascimento, M. Nooruzzaman, F. Yuan, C. Chen, L. C. Caserta, A. D. Miller, G. R. Whittaker, Y. Fang, D. G. Diel

This study shows that the Omicron BA.1.1 variant causes less severe disease, lower viral shedding, and reduced tissue replication compared to D614G and Delta variants in a feline model.

bioRxiv · Jun 15, 2022Microbiology

From Deer-to-Deer: SARS-CoV-2 is efficiently transmitted and presents broad tissue tropism and replication sites in white-tailed deer

M. Martins, P. M. Boggiatto, A. Buckley, E. D. Cassmann, S. Falkenberg, L. C. Caserta, M. H. V. Fernandes, C. Kanipe, K. Lager, M. V. Palmer, D. G. Diel

This study shows SARS-CoV-2 efficiently transmits between white-tailed deer and replicates in multiple tissues, highlighting their potential as a reservoir for the virus.

bioRxiv · Dec 14, 2021Microbiology

Protective efficacy of an orf virus-vector encoding the hemmagglutinin and the nucleoprotein of influenza A virus in swine

L. R. Joshi, D. Knudsen, P. Pineyro, S. Dhakal, G. J. Renukaradhya, D. G. Diel

This study evaluates two recombinant orf viruses expressing hemagglutinin (HA) or HA and nucleoprotein (NP) of IAV-S in pigs, finding that OV-HA-NP provides better protection against swine influenza with reduced virus shedding and viral load.

bioRxiv · Apr 19, 2021Immunology

Susceptibility of white-tailed deer (Odocoileus virginianus) to SARS-CoV-2

M. V. Palmer, M. Martins, S. Falkenberg, A. C. Buckley, L. C. Caserta, P. K. Mitchell, E. Cassmann, A. Rollins, N. C. Zylich, R. W. Renshaw, C. Guarino, B. Wagner, K. Lager, D. G. Diel

This study shows white-tailed deer are susceptible to SARS-CoV-2 infection, shedding virus in nasal secretions and transmitting it to contact animals.

bioRxiv · Jan 13, 2021Microbiology

SARS-CoV-2 Infection And Longitudinal Fecal Screening In Malayan Tigers (Panthera tigris jacksoni), Amur Tigers (Panthera tigris altaica), And African Lions (Panthera leo krugeri) At The Bronx Zoo, New York, USA

S. L. Bartlett, D. G. Diel, L. Wang, S. Zec, M. Laverack, M. Martins, L. C. Caserta, M. L. Killian, K. Terio, C. Olmstead, M. A. Delaney, T. Stokol, M. Ivancic, M. Jenkins-Moore, K. Ingerman, , P. P. Calle

This paper reports the first known natural SARS-CoV-2 transmission from humans to animals in the USA, documenting clinical signs, diagnostic findings, and prolonged fecal RNA shedding in tigers and lions.

bioRxiv · Aug 14, 2020Zoology

From people to Panthera: Natural SARS-CoV-2 infection in tigers and lions at the Bronx Zoo

D. McAloose, M. Laverack, L. Wang, M. L. Killian, L. C. Caserta, F. Yuan, P. K. Mitchell, K. Queen, M. R. Mauldin, B. D. Cronk, S. L. Bartlett, J. M. Sykes, S. Zec, T. Stokol, K. Ingerman, , D. G. Diel

The paper reports the first natural SARS-CoV-2 infections in tigers and lions at the Bronx Zoo, identifying two distinct viral strains and suggesting human-to-animal transmission.

bioRxiv · Jul 22, 2020Pathology