F. Yuan

Therapeutic Activity of Resolvin D1 (RvD1) in Murine MASH

This study investigates how RvD1 reduces inflammation, cell death, and fibrosis in MASH by targeting Stat1, ER stress, and MMP pathways.

The Alexander Disease Protein GFAP Drives Mitochondrial Fission

This study identifies GFAP as a novel mediator of mitochondrial fission by surrounding fission sites and modulating Drp1 recruitment, revealing a new mechanism in mitochondrial plasticity.

The first discovery of SFTSV in the Centre of Metropolitan Beijing, China

This study identifies SFTSV circulation in central Beijing by surveying ticks and hedgehogs, revealing high seroprevalence and RNA prevalence in urban areas.

Protein language models-assisted engineering of Uracil-N glycosylase enables programmable T-to-G and T-to-C base editing

This study uses protein language models to engineer a uracil-N-glycosylase variant for programmable T-to-G and T-to-C base editing, achieving high success rates in correcting genetic mutations in mice.

Mimetic butterfly wings through mimetic butterfly eyes

The paper tests if brightness vision, not color vision, helps Adelpha fessonia butterflies identify mates when their wing coloration is indistinguishable to birds.

Ubiquitin-driven protein condensation initiates clathrin-mediated endocytosis

This paper shows that ubiquitin stabilizes Eps15 condensates, which are essential for clathrin-mediated endocytosis, and that ubiquitylation regulates the dynamics of endocytic assemblies.

Harnessing Gradients for Self-Assembly of Peptide-Based Nanocapsules: A Pathway to Advanced Drug Delivery Systems

The paper describes the spontaneous formation of peptide-based nanocapsules through a solvent gradient-driven self-assembly process, offering a new approach for drug delivery systems.

Lipid droplets as substrates for protein phase separation

This study shows that intrinsically disordered proteins can undergo phase separation on lipid droplet surfaces, forming liquid-like protein-rich phases.

Development of monoclonal antibody-based blocking ELISA for detecting SARS-CoV-2 exposure in animals

This paper develops a monoclonal antibody-based blocking ELISA for detecting SARS-CoV-2 exposure in animals, achieving high sensitivity and specificity across multiple species.

Lateral compression of lipids drives transbilayer coupling of liquid-like protein condensates

This study shows that protein phase separation on both sides of a lipid bilayer is coupled through an entropic mechanism driven by lipid compression.

The ins and outs of membrane bending by intrinsically disordered proteins

This study investigates how intrinsically disordered proteins with both repulsive and attractive domains influence membrane curvature based on domain positioning and ionic strength.

Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents

The paper identifies a potent and broad sarbecovirus-neutralizing antibody cocktail, SA55+SA58, from SARS convalescents to combat Omicron variants and other fast-evolving viruses.

The Omicron variant BA.1.1 presents a lower pathogenicity than B.1 D614G and Delta variants in a feline model of SARS-CoV-2 infection

This study shows that the Omicron BA.1.1 variant causes less severe disease, lower viral shedding, and reduced tissue replication compared to D614G and Delta variants in a feline model.

KDM4A promotes the progression of neuroendocrine prostate cancer

This study identifies KDM4A as a key driver of neuroendocrine prostate cancer progression and shows that targeting KDM4A inhibits tumor growth in preclinical models.

Hedgehogs are the major amplifying hosts of severe fever with thrombocytopenia syndrome virus

This study identifies hedgehogs as the major amplifying hosts of SFTSV, showing they can sustain viral transmission cycles with ticks in both laboratory and natural settings.

Replication is the key barrier during the dual-host adaption of mosquito-borne flaviviruses

This study identifies key molecular factors determining mosquito-borne flavivirus host tropism by comparing insect-specific and dual-host flaviviruses.

Lung-selective Cas13d-based nanotherapy inhibits lethal SARS-CoV-2 infection by targeting host protease Ctsl

This paper develops a lung-selective Cas13d-based nanotherapy targeting Ctsl to inhibit SARS-CoV-2 infection, showing improved survival and reduced viral burden in mice.

From people to Panthera: Natural SARS-CoV-2 infection in tigers and lions at the Bronx Zoo

The paper reports the first natural SARS-CoV-2 infections in tigers and lions at the Bronx Zoo, identifying two distinct viral strains and suggesting human-to-animal transmission.

Membrane bending by protein phase separation

This paper investigates how liquid-like protein assemblies on membranes drive membrane bending by creating compressive stress, leading to the formation of membrane tubules.

Latent defense response to non-pathogenic microbial factors impairs plant-rhizobacteria mutualism

A hidden layer of host immunity against non-pathogenic microbes leads to plant incompatibility with beneficial rhizobacteria.

Cyniclomyces guttulatus is an opportunistic pathogen in rabbits with coccidiosis

This study isolates and characterizes Cyniclomyces guttulatus from diarrheic rabbits, showing it is not pathogenic alone but can exacerbate coccidiosis when co-inoculated with Eimeria intestinalis.

DNA 5-Hydroxymethylcytosines from Cell-free Circulating DNA as Diagnostic Biomarkers for Human Cancers

The paper identifies 5hmC signatures in cfDNA as accurate biomarkers for detecting colorectal and gastric cancers, outperforming conventional markers and matching tissue biopsy results.