A. Saxena

Highly Pathogenic Avian Influenza A (H5N1) clade 2.3.4.4b Virus detected in dairy cattle

The paper identifies a new genotype of HPAI H5N1 virus in dairy cattle, showing genetic changes but lacking key mutations for mammalian adaptation.

Evaluation Of Suitability Analysis of Gangetic Water from Upper, Middle, And Lower Ganga Rivers

This study evaluates water quality across the Ganga River's upper, middle, and lower stretches to determine suitability for drinking, irrigation, and industrial use, highlighting variations in parameters like E. coli, sodium levels, and heavy metals.

Polymer-mediated oligonucleotide delivery enables construction of barcoded 3D cultures for spatial single-cell analysis

The paper introduces a method to create barcoded 3D cell cultures for spatial single-cell analysis using polymer-mediated oligonucleotide delivery and multiplex single-cell RNA sequencing.

Single cell transcriptomics reveals cell type specific features of developmentally regulated responses to lipopolysaccharide between birth and 5 years.

This study uses single cell RNA-sequencing to compare the transcriptional responses to LPS in cord blood and 5-year-old peripheral blood mononuclear cells, revealing developmental changes in immune cell signaling and communication.

Epigenetic mediated functional reprogramming of immune cells leads to HBsAg seroconversion in Hepatitis B Virus Reactivation patients

This study identifies epigenetic changes in HBV reactivation patients that drive immune and metabolic reprogramming, leading to HBsAg seroconversion.

Progressive plasticity during colorectal cancer metastasis

This study identifies progressive plasticity in colorectal cancer metastases, showing reprogramming into fetal progenitor states and divergent differentiation, linked to poor survival.

Patient-derived xenografts and single-cell sequencing identifies three subtypes of tumor-reactive lymphocytes in uveal melanoma metastases

Metabolic alterations unravel the materno fetal immune responses with disease severity in pregnant women infected with SARS-CoV-2

This study examines metabolic and immune changes in pregnant women with SARS-CoV-2 infection, finding altered metabolic pathways and cytokine profiles associated with disease severity.

BESFA: Bioinformatics based Evolutionary, Structural & Functional Analysis of Prostrate, Placenta, Ovary, Testis, and Embryo (POTE) Paralogs

This study analyzes the POTE protein family to understand their structure, function, and adaptive divergence, identifying potential therapeutic applications in cancer.

Mycobacterium abscessus HelR interacts with RNA Polymerase to confer intrinsic rifamycin resistance

This paper identifies MabHelR as a factor conferring inducible rifamycin resistance in M. abscessus by interacting with RNA polymerase to disassemble RIF-stalled complexes.

Potent SARS-CoV-2 neutralizing antibodies selected from a human antibody library constructed decades ago

The paper identifies potent SARS-CoV-2 neutralizing antibodies from a pre-pandemic human antibody library, showing high somatic hypermutation and specific binding to the spike protein.

Secondary ossification center induces and protects growth plate structure

This study identifies the secondary ossification center's role in protecting growth plate hypertrophic chondrocytes from mechanical stress during terrestrial adaptation.

Systems Biology under heat stress in Indian Cattle

This study compares gene expression under heat stress in two Indian cattle breeds, finding Tharparkar better adapts through upregulated stress response and antioxidant genes.

Addition of insoluble fiber to isolation media allows for increased metabolite diversity of lab-cultivable microbes derived from zebrafish gut samples

This study shows that adding insoluble fiber to isolation media increases microbial diversity and unique metabolite production from zebrafish gut microbes.

Engineered niches support the development of human dendritic cells in humanized mice

This study shows engineered mesenchymal stromal cells can generate human dendritic cells in vivo, closely resembling blood-derived cDCs.

Lipid Lowering Oxopropanylindole Hydrazone Derivatives with Anti-oxidant and Anti-hyperglycemic Activity

This study synthesizes and evaluates oxopropanylindole hydrazone derivatives for antioxidant and anti-dyslipidemic activity, identifying 6c as the most effective compound.

The mutational decay of male and hermaphrodite competitive fitness in the androdioecious nematode C. elegans, in which males are naturally rare

The paper estimates mutational effects on male and hermaphrodite competitive fitness in C. elegans, finding males decay faster due to higher mutation rates and mating variability.