Author

D. Iaconis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

A. R. Beccari· 3 shared C. Talarico· 3 shared M. Allegretti· 3 shared M. Michaelides· 2 shared R. Bertini· 2 shared A. Caruso· 1 shared A. Cimini· 1 shared A. Napiorkowski· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersCell Biology

A. R. Beccari

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Relevance of the viral Spike protein/cellular Estrogen Receptor-α interaction for endothelial-based coagulopathy induced by SARS-CoV-2

S. S. Barbieri, F. Cattani, L. Sandrini, M. M. Grillo, C. Talarico, D. Iaconis, L. Lione, E. Salvatori, P. Amadio, G. Garoffolo, M. Maffei, F. Galli, A. R. Beccari, E. Marra, M. Zoppi, , M. Pesce

This study investigates how the SARS-CoV-2 Spike protein interacts with the estrogen receptor-α to enhance pro-coagulant activity in endothelial cells, leading to thrombosis risk.

bioRxiv · Oct 4, 2022 · PreprintCell Biology

The SARS-CoV-2 spike protein binds and modulates estrogen receptors

O. Solis, A. R. Beccari, D. Iaconis, C. Talarico, C. A. Ruiz-Bedoya, J. C. Nwachukwu, A. Cimini, V. Castelli, R. Bertini, M. Montopoli, V. Cocetta, S. Borocci, I. G. Prandi, K. Flavahan, M. Bahr, , M. Michaelides

This study identifies a novel interaction between SARS-CoV-2 spike protein and estrogen receptor alpha, showing its role in modulating ER activity and ACE2 expression in infected cells and tissues.

bioRxiv · May 21, 2022Immunology

Characterization of raloxifene as potential pharmacological agent against SARS-CoV-2 and its variants

D. Iaconis, C. Talarico, C. Manelfi, M. C. Cesta, M. Zippoli, F. Caccuri, G. Matusali, L. Bordi, L. Scorzolini, E. M. Bucci, A. Caruso, E. Nicastri, M. Allegretti, A. R. Beccari

This paper identifies raloxifene as a potential drug candidate for treating COVID-19 through virtual screening and pharmacological characterization across multiple viral variants.

bioRxiv · Oct 22, 2021Pharmacology & Toxicology