M. Allegretti

Relevance of the viral Spike protein/cellular Estrogen Receptor-α interaction for endothelial-based coagulopathy induced by SARS-CoV-2

This study investigates how the SARS-CoV-2 Spike protein interacts with the estrogen receptor-α to enhance pro-coagulant activity in endothelial cells, leading to thrombosis risk.

Targeting C5aR1 signaling reduced neutrophil extracellular traps and ameliorates COVID-19 pathology

This study shows that inhibiting C5aR1 signaling reduces neutrophil extracellular traps and improves lung pathology in COVID-19.

The SARS-CoV-2 spike protein binds and modulates estrogen receptors

This study identifies a novel interaction between SARS-CoV-2 spike protein and estrogen receptor alpha, showing its role in modulating ER activity and ACE2 expression in infected cells and tissues.

Characterization of raloxifene as potential pharmacological agent against SARS-CoV-2 and its variants

This paper identifies raloxifene as a potential drug candidate for treating COVID-19 through virtual screening and pharmacological characterization across multiple viral variants.

In cell architecture of the nuclear pore complex and snapshots of its turnover

The paper uses structural biology and yeast genetics to study NPC architecture and turnover in yeast cells, revealing new insights into mRNA export and autophagy mechanisms.

Cone-shaped HIV-1 capsids are transported through intact nuclear pores

The paper shows HIV-1 capsids can enter the nucleus intact through nuclear pores, challenging the idea that uncoating must occur before nuclear import.

Nuclear pores constrict upon energy depletion

This study shows that nuclear pore complexes constrict when cells experience energy depletion, linking cellular energy status to NPC conformation.

An ESCRT-LEM domain inner nuclear membrane protein surveillance system is poised to directly monitor the integrity of the nuclear envelope barrier and nuclear transport system

The paper identifies a surveillance system in yeast that detects and seals nuclear envelope damage through ESCRT and inner nuclear membrane proteins.