Smoothened Transduces Hedgehog Signals via Activity-Dependent Sequestration of PKA Catalytic Subunits
C. D. Arveseth, J. T. Happ, D. S. Hedeen, J.-F. Zhu, J. L. Capener, D. K. Shaw, I. Deshpande, J. Liang, J. Xu, S. L. Stubben, I. B. Nelson, M. F. Walker, N. J. Krogan, D. J. Grunwald, R. Hüttenhain, , B. R. Myers
This study reveals that Smoothened (SMO) activates GLI transcription factors by sequestering PKA catalytic subunits at the membrane, bypassing traditional GPCR signaling mechanisms.
bioRxiv · Jul 1, 2020Biochemistry