Author

J. T. Happ

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2

Frequent Co-Authors

B. R. Myers· 2 shared C. D. Arveseth· 2 shared D. S. Hedeen· 2 shared I. B. Nelson· 2 shared J. L. Capener· 2 shared J.-F. Zhu· 2 shared A. Manglik· 1 shared C. C. King· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersBiochemistry

B. R. Myers

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2 papers

Recent·Most cited

A PKA Inhibitor Motif within Smoothened Controls Hedgehog Signal Transduction

J. T. Happ, C. D. Arveseth, J. Bruystens, D. Bertinetti, I. B. Nelson, C. Olivieri, D. S. Hedeen, J.-F. Zhu, J. L. Capener, J. W. Bröckel, L. Vu, C. C. King, V. L. Ruiz-Perez, G. Veglia, F. W. Herberg, , B. R. Myers

This study identifies a PKA inhibitor motif in Smoothened that blocks PKA activity, enabling GLI activation in the Hedgehog pathway, revealing a mechanism similar to the Wnt cascade.

bioRxiv · Jul 5, 2021Biochemistry

Smoothened Transduces Hedgehog Signals via Activity-Dependent Sequestration of PKA Catalytic Subunits

C. D. Arveseth, J. T. Happ, D. S. Hedeen, J.-F. Zhu, J. L. Capener, D. K. Shaw, I. Deshpande, J. Liang, J. Xu, S. L. Stubben, I. B. Nelson, M. F. Walker, N. J. Krogan, D. J. Grunwald, R. Hüttenhain, , B. R. Myers

This study reveals that Smoothened (SMO) activates GLI transcription factors by sequestering PKA catalytic subunits at the membrane, bypassing traditional GPCR signaling mechanisms.

bioRxiv · Jul 1, 2020Biochemistry