Author

D. K. Shaw

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

E. A. Fisk· 2 shared J. Hurtado· 2 shared J. M. Park· 2 shared K. L. Rosche· 2 shared L. C. Sidak-Loftis· 2 shared L. Marnin· 2 shared L. R. Butler· 2 shared N. Singh· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersMicrobiology

E. A. Fisk

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Rab27 in tick extracellular vesicle biogenesis and infection

L. R. Butler, N. Singh, L. Marnin, L. Valencia, A. O'Neal, F. Cabrera Paz, D. K. Shaw, A. Oliva Chavez, J. Pedra

This study identifies Rab27 as essential for tick extracellular vesicle biogenesis and its role in bacterial acquisition during feeding.

bioRxiv · Nov 2, 2023 · PreprintMicrobiology

PERK-mediated antioxidant response is key for pathogen persistence in ticks

K. L. Rosche, J. Hurtado, E. A. Fisk, K. A. Vosbigian, A. L. Warren, L. C. Sidak-Loftis, S. J. Wright, E. Ramirez-Zepp, J. M. Park, D. K. Shaw

This study shows that the PERK pathway in ticks helps pathogens persist by enhancing an antioxidant response regulated by Nrf2.

bioRxiv · May 30, 2023Microbiology

An Anaplasma phagocytophilum T4SS effector, AteA, is essential for tick infection

J. M. Park, B. M. Genera, D. Fahy, K. T. Swallow, C. M. Nelson, J. D. Oliver, D. K. Shaw, U. G. Munderloh, K. A. Brayton

This study identifies AteA, an Anaplasma phagocytophilum effector essential for tick infection but dispensable in mammals, revealing its role in actin manipulation for arthropod colonization.

bioRxiv · Feb 6, 2023 · PreprintMicrobiology

CD36 homologs determine microbial resistance to the Lyme disease spirochete

A. J. O'Neal, N. Singh, I. S. Forrest, A. Rolandelli, X. Wang, D. K. Shaw, B. D. Young, S. Narasimhan, S. Dutta, G. A. Snyder, L. Marnin, L. R. Butler, S. Samaddar, M. T. Mendes, F. E. C. Paz, , J. H. F. Pedra

The paper identifies CD36 homologs as conserved lipid receptors mediating anti-Borrelia immunity in both ticks and humans.

bioRxiv · Feb 9, 2022 · PreprintImmunology

The unfolded protein response triggers the immune deficiency pathway in ticks

L. C. Sidak-Loftis, K. L. Rosche, N. Pence, J. K. Ujczo, J. Hurtado, E. A. Fisk, A. G. Goodman, S. M. Noh, J. W. Peters, D. K. Shaw

The study shows that the unfolded protein response (UPR) initiates the immune deficiency (IMD) pathway in ticks, linking ER stress to pathogen restriction.

bioRxiv · Aug 31, 2021 · PreprintImmunology

Smoothened Transduces Hedgehog Signals via Activity-Dependent Sequestration of PKA Catalytic Subunits

C. D. Arveseth, J. T. Happ, D. S. Hedeen, J.-F. Zhu, J. L. Capener, D. K. Shaw, I. Deshpande, J. Liang, J. Xu, S. L. Stubben, I. B. Nelson, M. F. Walker, N. J. Krogan, D. J. Grunwald, R. Hüttenhain, , B. R. Myers

This study reveals that Smoothened (SMO) activates GLI transcription factors by sequestering PKA catalytic subunits at the membrane, bypassing traditional GPCR signaling mechanisms.

bioRxiv · Jul 1, 2020Biochemistry