Increased isoDGR motifs in plasma fibronectin are associated with atherosclerosis through facilitation of vascular fibrosis
J. E. Park, X. Guo, K. C. K. Liou, S. E. Lynn, S. S. Ng, W. Meng, S. C. Lim, M. K.-S. Leow, A. M. Richards, D. J. Pennington, N. E. McCarthy, D. P. V. de Kleijn, V. Sorokin, H. H. Ho, S. K. Sze
This study shows that deamidated fibronectin with isoDGR motifs promotes vascular fibrosis and atherosclerosis by enhancing integrin signaling and leukocyte recruitment.
bioRxiv · Jul 21, 2020 · PreprintBiochemistry