Author

N. E. McCarthy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

S. K. Sze· 3 shared J. E. Park· 2 shared A. M. Richard· 1 shared A. M. Richards· 1 shared B. S. Bhargy Sharma· 1 shared B. S. T. Lee· 1 shared C. P. Chen· 1 shared D. J. Pennington· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersPathology

S. K. Sze

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Age-linked lung pathology is reduced by immunotherapeutic targeting of isoDGR protein damage

P. Kalailingam, K.-H. Mohd-Kahliab, S. C. N. SoFong Cam Ngan, R. Iyappan, B. S. T. Lee, B. S. Bhargy Sharma, R. Machan, S. T. Bo, E. S. Chambers, V. A. Fajardo, R. E. K. Macpherson, J. Liu, P. Klentrou, E. L. Tsiani, K. L. Lim, , S. K. Sze

This study identifies isoDGR-damaged proteins as contributors to age-related lung pathology and shows that anti-isoDGR antibodies reduce lung damage in mice.

bioRxiv · Aug 11, 2023 · PreprintPathology

Increased isoDGR motifs in plasma fibronectin are associated with atherosclerosis through facilitation of vascular fibrosis

J. E. Park, X. Guo, K. C. K. Liou, S. E. Lynn, S. S. Ng, W. Meng, S. C. Lim, M. K.-S. Leow, A. M. Richards, D. J. Pennington, N. E. McCarthy, D. P. V. de Kleijn, V. Sorokin, H. H. Ho, S. K. Sze

This study shows that deamidated fibronectin with isoDGR motifs promotes vascular fibrosis and atherosclerosis by enhancing integrin signaling and leukocyte recruitment.

bioRxiv · Jul 21, 2020 · PreprintBiochemistry

ERO1α promotes hypoxic tumour progression and is associated with poor prognosis in pancreatic cancer

N. Gupta, J. E. Park, W. Tse, L. J. Kim, O. L. Kon, N. E. McCarthy, S. K. Sze

This study identifies ERO1α as a key driver of hypoxic pancreatic tumour progression and poor prognosis, supported by proteomic analysis and functional validation.

bioRxiv · Jun 6, 2019Cancer Biology