Author

C. M. Webb

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

D. P. Kelsell· 2 shared A. Alon· 1 shared A. C. Kruse· 1 shared A. Chikh· 1 shared A. I. Basbaum· 1 shared A. Tinker· 1 shared B. K. Shoichet· 1 shared B. L. Roth· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCell Biology

D. P. Kelsell

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Author profile →

3 papers

Recent·Most cited

Cleavage of the pseudoprotease iRhom2 by the signal peptidase complex reveals an ER-to-nucleus signalling pathway

I. Dulloo, M. Tellier, C. Levet, A. Chikh, B. Zhang, C. M. Webb, D. P. Kelsell, M. Freeman

The paper identifies a novel ER-to-nucleus signaling pathway mediated by iRhom2 cleavage by the signal peptidase complex, linking it to psoriasis and TOC.

bioRxiv · Nov 28, 2022 · PreprintCell Biology

Crystal structures of the σ2 receptor template large-library docking for selective chemotypes active in vivo

A. Alon, J. Lyu, J. M. Braz, T. A. Tummino, V. Craik, M. J. O'Meara, C. M. Webb, D. S. Radchenko, Y. S. Moroz, X.-P. Huang, Y. Liu, B. L. Roth, J. J. Irwin, A. I. Basbaum, B. K. Shoichet, A. C. Kruse

This study uses crystal structures of the σ2 receptor to dock and screen a large library, identifying new chemotypes with high affinity and selectivity for the receptor.

bioRxiv · Apr 29, 2021Pharmacology & Toxicology

Early cardiac inflammation as a driver of murine model of Arrhythmogenic Cardiomyopathy

K.-E. Ng, P. J. Delaney, D. Thenet, S. Murtough, C. M. Webb, E. Tsisanova, S. L. Walker, J. D. Westaby, D. J. Pennington, R. Pink, D. P. Kelsell, A. Tinker

The paper identifies early cardiac inflammation as a key driver in a murine model of arrhythmogenic cardiomyopathy, linking desmoglein 2 loss to inflammatory pathway activation and fibrosis.

bioRxiv · Jun 24, 2020 · PreprintImmunology