D. J. Topham

Mouse Memory CD8 T cell subsets defined by Tissue Resident Memory (TRM) Integrin Expression Exhibit Distinct Metabolic Profiles

This study identifies distinct metabolic profiles in mouse lung TRM subsets defined by integrin expression and shows that nutrient conditions influence their differentiation.

Genetic Variation and Disease Severity of Respiratory Syncytial Viruses

This study investigates the association between RSV genetic variations and disease severity in infants, finding significant links between phylogeny and specific protein variations in different subtypes.

CD49a Identifies Polyfunctional Memory CD8 T cell Subsets that Persist in the Lungs after Influenza Infection

This study identifies CD49a-expressing polyfunctional CD8 memory subsets in lung tissue that persist after influenza infection and exhibit diverse effector functions.

Interference at Influenza Hemagglutinin Antigenic-Sites Determines Antibody Levels and Specificities after Repeat Vaccination

The paper simulates how pre-existing immunity affects antibody levels and specificities after repeat influenza vaccination, finding that antibody-mediated clearance and germinal center formation play key roles.

Temporal Dysbiosis of Infant Nasal Microbiota Relative to Respiratory Syncytial Virus Infection

This study examines the temporal changes in infant nasal microbiota relative to RSV infection and identifies taxa associated with infection and disease severity.

S protein-reactive IgG and memory B cell production after human SARS-CoV-2 infection includes broad reactivity to the S2 subunit

This study examines IgG and memory B cell responses to SARS-CoV-2 infection, finding broad reactivity to the S2 subunit and durable B cell immunity.

Aberrant newborn T cell and microbiota developmental trajectories predict respiratory compromise during infancy

The paper identifies that prenatal antibiotics or infection disrupt T cell and microbiota development, increasing respiratory morbidity risk in infants.

Array-based analysis of SARS-CoV-2, other coronaviruses, and influenza antibodies in convalescent COVID-19 patients

The paper develops an antigen microarray to detect antibodies against SARS-CoV-2, other coronaviruses, and influenza in convalescent COVID-19 patients, showing it can distinguish infected from uninfected individuals and measure antibody levels.

TRM Integrins CD103 and CD49a Differentially Support Adherence and Motility After Resolution of Influenza Virus Infection

This study shows CD103 and CD49a on TRM cells have distinct roles in adherence and motility, impacting TRM retention and host protection after influenza infection.

Airway Gene-Expression Classifiers for Respiratory Syncytial Virus (RSV) Disease Severity in Infants

The paper develops gene expression classifiers from nasal brush samples to predict RSV disease severity in infants, finding strong correlations with clinical scores.

Antigen and G-Protein Coupled Receptor signaling differentially control CD8 T cell motility immediately before and after virus clearance in a primary infection

This study examines how antigen and chemokine signals influence CD8 T cell motility during influenza infection, showing that antigen signals promote mobility while chemokine signals restrict it, with a shift observed on day 9 post-infection.

Computer Simulations of the Humoral Immune System Reveal How Imprinting Can Affect Responses to Influenza HA Stalk with Implications for the Design of Universal Vaccines

The paper uses computer simulations to show that prior exposure to antigenically dissimilar strains can enhance cross-reactive antibody responses to conserved influenza HA regions, with implications for universal vaccine design.