Author

T. J. Mariani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Assay:bulk RNA-seq· 4 Research Focus:host-pathogen & immune response· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Assay:metagenomics· 1

Frequent Co-Authors

A. Corbett· 3 shared D. J. Topham· 3 shared X. Qiu· 3 shared A. Grier· 2 shared A. R. Falsey· 2 shared C. S. Anderson· 2 shared E. E. Walsh· 2 shared E. Walsh· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersMicrobiology

A. Corbett

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Author profile →

5 papers

Recent·Most cited

Generation and functional analysis of defective viral genomes during SARS-CoV-2 infection

T. Zhou, N. J. Gilliam, S. Li, S. Spaudau, R. Osborn, C. S. Anderson, T. J. Mariani, J. Thakar, S. Dewhurst, D. H. Mathews, L. Huang, Y. Sun

This study identifies DVG generation in SARS-CoV-2 and links it to IFN stimulation and persistent infection, showing higher DVG levels in symptomatic patients.

bioRxiv · Sep 22, 2022Microbiology

Genetic Variation and Disease Severity of Respiratory Syncytial Viruses

C. S. Anderson, Y. Zhang, A. Corbett, C. Chu, A. Grier, L. Wang, X. Qiu, M. Mccall, D. J. Topham, E. Walsh, T. J. Mariani, R. H. Scheuermann, M. Caserta

This study investigates the association between RSV genetic variations and disease severity in infants, finding significant links between phylogeny and specific protein variations in different subtypes.

bioRxiv · Feb 28, 2022 · PreprintMicrobiology

CX3CR1 Engagement by Respiratory Syncytial Virus Leads to Induction of Nucleolin and Dysregulation of Cilia-related Genes

C. Anderson, T. Chirkova, C. G. Slaunwhite, X. Qiu, E. Walsh, L. J. Anderson, T. J. Mariani

This study shows that RSV infection via CX3CR1 engagement induces Nucleolin and suppresses cilia-related genes, with CX3C motif mutation reversing these effects.

Journal of Virology · May 10, 2021Peer-reviewedMicrobiology

Temporal Dysbiosis of Infant Nasal Microbiota Relative to Respiratory Syncytial Virus Infection

A. Grier, A. L. Gill, H. A. Kessler, A. Corbett, S. Bandyopadhyay, J. Java, J. Holden-Wiltse, A. R. Falsey, D. J. Topham, T. J. Mariani, M. T. Caserta, E. E. Walsh, S. R. Gill

This study examines the temporal changes in infant nasal microbiota relative to RSV infection and identifies taxa associated with infection and disease severity.

The Journal of Infectious Diseases · Sep 14, 2020Peer-reviewedMicrobiology

Airway Gene-Expression Classifiers for Respiratory Syncytial Virus (RSV) Disease Severity in Infants

L. Wang, C.-Y. Chu, M. N. McCall, C. Slaunwhite, J. Holden-Wiltse, A. Corbett, A. R. Falsey, D. J. Topham, M. T. Caserta, T. J. Mariani, E. E. Walsh, X. Qiu

The paper develops gene expression classifiers from nasal brush samples to predict RSV disease severity in infants, finding strong correlations with clinical scores.

bioRxiv · May 9, 2020Immunology