Author

D. L. Kasper

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biochemistry· 1 Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Assay:metagenomics· 4 Organism:mouse· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

M. Wu· 4 shared B. Bao· 2 shared F. S. Gazzaniga· 2 shared T. Yang· 2 shared W. Zheng· 2 shared X. Song· 2 shared Y. Wang· 2 shared A. Dinis· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersImmunology

M. Wu

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Top-down Mass Spectrometric Analysis of a Lipooligosaccharide from the Human Commensal Bacteroides fragilis

T. Yang, J. Daugherty, D. L. Kasper

This study uses top-down mass spectrometry to determine the detailed structure of B. fragilis lipooligosaccharide, revealing its poly-galactose-rhamnose-KDO-lipid A architecture and modifications.

bioRxiv · Apr 13, 2024 · PreprintBiochemistry

Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 Production.

B. Bao, Y. Wang, P. Boudreau, X. Song, M. Wu, X. Chen, I. Patik, Y. Tang, J. D. Ouahed, A. Ringel, J. Barends, C. Wu, E. P. Balskus, J. R. Thiagarajah, J. Liu, , S. Snapper

This study shows that bacterial sphingolipids worsen colitis by reducing IL-22 production from ILC3 cells in mice.

bioRxiv · Sep 5, 2023Immunology

Functional and metagenomic level diversities of human gut symbiont-derived glycolipids

J.-S. Yoo, B. Goh, K. Heo, D.-J. Jung, W. Zheng, C. C. Lee, N. Geva-Zatorsky, M. Wu, S. B. Park, D. L. Kasper, S. F. Oh

The paper investigates the functional and metagenomic diversity of glycolipids produced by gut symbionts, revealing distinct biosynthetic pathways and immune-modulatory roles of different microbial species.

bioRxiv · May 23, 2023Microbiology

Microbiome induced complement synthesized in the gut protects against enteric infections

M. Wu, W. Zheng, X. Song, B. Bao, Y. Wang, D. Ramanan, D. Yang, R. Liu, J. C. Macbeth, E. A. Do, W. A. Andrade, T. Yang, H.-S. Cho, F. S. Gazzaniga, M. Ilves, , D. L. Kasper

The paper shows gut microbiota regulate complement component 3 (C3) production in humans and mice, with intestinal C3 levels correlating with protection against enteric infections.

bioRxiv · Feb 2, 2023 · PreprintImmunology

Harnessing Colon Chip technology to identify commensal bacteria that promote host tolerance to infection

F. S. Gazzaniga, D. Camacho, M. Wu, M. F. D. S. Palazzo, A. Dinis, F. N. Grafton, M. J. Cartwright, M. Super, D. L. Kasper, D. E. Ingber

The paper uses a microfluidic organ-on-a-chip model to identify commensal bacteria that enhance host tolerance to infection, finding Enterococcus faecium promotes tolerance.

bioRxiv · Dec 5, 2020Bioengineering

Anatomically remote education of B cells is required for colonic health

N. Surana, C. J. Couter, D. Alvarez, U. H. von Andrian, D. L. Kasper

This study shows that B cells educated in Peyer's patches are critical for colonic health, as they produce IgA and restrain inflammation in the colon.

bioRxiv · Oct 17, 2019 · PreprintImmunology