Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 Production.
B. Bao, Y. Wang, P. Boudreau…·S. Snapper
This study shows that bacterial sphingolipids worsen colitis by reducing IL-22 production from ILC3 cells in mice.
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6 papers
Recent·Most cited
B. Bao, Y. Wang, P. Boudreau…·S. Snapper
This study shows that bacterial sphingolipids worsen colitis by reducing IL-22 production from ILC3 cells in mice.
M. Kalashyan, K. Raghunathan, H. Oller…·J. R. Thiagarajah
This study uses patient-derived enteroids to model Microvillus Inclusion Disease and identifies therapeutic strategies targeting Notch signaling and chloride channels.
P. Devant, E. Borsic, E. M. Ngwa…·J. C. Kagan
This study shows that reactive oxygen species (ROS) oxidize gasdermin D (GSDMD), promoting its assembly into a pore-forming complex and enhancing pyroptosis.
B. Sposito, J. Mambu, K. Bugda Gwilt…·I. Zanoni
This study shows type III interferons delay intestinal tissue repair by inducing pyroptosis in epithelial cells after injury.
M. J. Grey, H. De Luca, D. V. Ward…·W. I. Lencer
This study shows IRE1β is essential for microbiota-induced goblet cell maturation and mucus barrier assembly in the colon, shaping gut microbiota composition through ER stress regulation.
M. J. Grey, E. Cloots, M. S. Simpson…·W. I. Lencer
This study shows IRE1β suppresses IRE1α signaling during ER stress by blocking its activation and disrupting a feedback loop that regulates IRE1 expression.