Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation
J. J. Chen, D. L. Nathaniel, P. Raghavan, M. Nelson, R. Tian, E. Tse, J. Y. Hong, S. K. See, S.-A. Mok, M. Y. Hein, D. R. Southworth, L. T. Grinberg, J. E. Gestwicki, M. D. Leonetti, M. Kampmann
The paper identifies ESCRT pathway components as regulators of tau aggregation propagation by enabling endolysosomal escape of tau seeds.
bioRxiv · Sep 26, 2019Cell Biology