Author

M. Y. Hein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:human· 4 Assay:proteomics· 4 Research Focus:cell-cell communication· 3 Approach:experimental assay· 3 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2

Frequent Co-Authors

F. McCarthy· 3 shared M. D. Leonetti· 3 shared D. N. Itzhak· 2 shared J. E. Elias· 2 shared J. Winkler· 2 shared K. Kim· 2 shared L. Savy· 2 shared M. Borja· 2 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersCell Biology

F. McCarthy

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Spatio-temporal analysis of Vaccinia virus infection and host response dynamics using single-cell transcriptomics and proteomics

A. Matia, F. McCarthy, H. Woosley, V. Turon-Lagot, S. W. Platzer, J. Liu, M. M. Lorenzo, M. Borja, K. Shetty, J. Winkler, J. E. Elias, R. Blasco, C. Arias, M. Y. Hein

This study uses single-cell transcriptomics and proteomics to analyze Vaccinia virus infection dynamics and host response heterogeneity in HeLa and fibroblast cells.

bioRxiv · Jan 13, 2024 · PreprintMicrobiology

Global organelle profiling reveals subcellular localization and remodeling at proteome scale

M. Y. Hein, D. Peng, V. Todorova, F. McCarthy, K. Kim, C. Liu, L. Savy, C. Januel, R. Baltazar-Nunez, S. Bax, S. Vaid, M. Vangipuram, I. E. Ivanov, J. R. Byrum, S. Pradeep, , M. D. Leonetti

The paper maps subcellular localization of human proteins and shows proteome remodeling during viral infection by combining organelle immuno-capture with mass spectrometry.

bioRxiv · Dec 18, 2023Cell Biology

Dissecting the contributions of tumor heterogeneity on metastasis at single-cell resolution

J. Winkler, W. Tan, C. M. M. Diadhiou, C. S. McGinnis, A. Abbasi, S. Hasnain, S. Durney, E. Atamaniuc, D. Superville, L. Awni, J. V. Lee, J. H. Hinrichs, M. Y. Hein, M. Borja, A. Detweiler, , Z. Werb

This study analyzes single-cell transcriptomes of primary tumors and metastases from breast cancer models, identifying transcriptional differences and gene signatures linked to metastatic potential and patient outcomes.

bioRxiv · Aug 4, 2022 · PreprintCancer Biology

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

N. H. Cho, K. C. Cheveralls, A.-D. Brunner, K. Kim, A. C. Michaelis, P. Raghavan, H. Kobayashi, L. Savy, J. Y. Li, H. Canaj, J. Y. S. Kim, E. M. Setwart, C. Gnann, F. McCarthy, J. P. Cabrera, , M. D. Leonetti

The paper maps human protein localization and interactions using genome engineering, imaging, and data science, revealing functional communities and RNA-binding protein subgroups.

bioRxiv · Mar 29, 2021Cell Biology

Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation

J. J. Chen, D. L. Nathaniel, P. Raghavan, M. Nelson, R. Tian, E. Tse, J. Y. Hong, S. K. See, S.-A. Mok, M. Y. Hein, D. R. Southworth, L. T. Grinberg, J. E. Gestwicki, M. D. Leonetti, M. Kampmann

The paper identifies ESCRT pathway components as regulators of tau aggregation propagation by enabling endolysosomal escape of tau seeds.

bioRxiv · Sep 26, 2019Cell Biology