Author

D. L. Sackett

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:imaging· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

A. Basseville· 1 shared A. Pasut· 1 shared B. Roarke· 1 shared C. Sourbier· 1 shared G. Alspaugh· 1 shared H. Gu· 1 shared J. R. Knutson· 1 shared K. Mukherjee· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperCancer Biology

A. Basseville

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Author profile →

3 papers

Recent·Most cited

High resolution spatial investigation of intracellular oxygen in muscle cells.

R. Penjweini, A. Pasut, B. Roarke, G. Alspaugh, D. L. Sackett, J. R. Knutson

This paper introduces a genetically encoded O2 sensor to measure intracellular oxygen levels in muscle cells and links O2 dynamics to muscle differentiation.

bioRxiv · Jul 18, 2023 · PreprintCell Biology

Histone deacetylase inhibitor induces acetyl-CoA depletion leading to lethal metabolic stress in RAS-pathway activated cells

A. Basseville, P.-C. Violet, M. Safari, C. Sourbier, M. Linehan, R. W. Robey, M. Levine, D. L. Sackett, S. E. Bates

This study shows that the HDAC inhibitor romidepsin induces acetyl-CoA depletion and metabolic stress in KRAS-activated cells, linking HDACi sensitivity to acetyl-CoA metabolism pathways.

bioRxiv · Jan 31, 2022Cancer Biology

A Highly Sensitive Fluorogenic Assay for the Detection of Nephrotoxin-Induced Oxidative Stress in Live Cells and Renal Tissue

K. Mukherjee, T. I. Chio, H. Gu, D. L. Sackett, S. L. Bane, S. Sever

This paper develops a fluorogenic assay to detect oxidative stress in live cells and renal tissue, showing improved sensitivity for identifying early signs of nephrotoxicity.

bioRxiv · Jun 1, 2020Biochemistry