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Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
10 papers
Recent·Most cited
J. M. Gonzalez Dalmasy, C. Fitzsimmons, W. J. E. Frye, A. J. Perciaccante, C. P. Jewell, L. M. Jenkins, P. J. Batista, R. W. Robey, M. M. Gottesman
This study shows that TMT1A's ability to methylate thiol-based HDAC inhibitors is conserved across species, suggesting its functional relevance in animal models.
bioRxiv · Nov 17, 2023Pharmacology & Toxicology
C. T. Inglut, J. A. Quinlan, R. W. Robey, J. R. Thomas, J. R. Walker, W. Zhou, H.-C. Huang, M. M. Gottesman
The paper identifies NanoLuciferase substrates transported by human and zebrafish ABC transporters at the BBB, aiding in the development of a transgenic zebrafish model to detect BBB disruptors.
bioRxiv · Oct 20, 2023 · PreprintPharmacology & Toxicology
Y. Pang, Q. Li, Z. Sergi, G. Yu, X. Sang, O. Kim, H. Wang, A. Ranjan, M. Merchant, B. Oudit, R. W. Robey, F. Soheilian, B. Tran, F. J. Nunez, M. Zhang, , J. Wu
This paper identifies zotiraciclib as a therapeutic agent targeting IDH-mutant gliomas by disrupting mitochondrial function and inducing oxidative stress, leading to a clinical trial.
bioRxiv · Jun 29, 2023Cancer Biology
J. R. Thomas, W. J. E. Frye, R. W. Robey, A. C. Warner, D. Butcher, J. L. Matta, T. C. Morgan, E. F. Edmondson, P. B. Salazar, S. Ambudkar, M. M. Gottesman
The paper identifies Abcg2a as the functional homolog of human ABCG2 at the zebrafish blood-brain barrier, showing its substrate overlap and BBB localization.
bioRxiv · May 18, 2023Cell Biology
W. J. E. Frye, L. M. Huff, J. M. G. Dalmasy, P. Salazar, R. M. Carter, R. T. Gensler, D. Esposito, R. W. Robey, S. V. Ambudkar, M. M. Gottesman
This study shows that P-glycoprotein (P-gp) and ABCG2 confer resistance to ferroptosis inducers, and some inducers inhibit these transporters, suggesting potential drug-drug interactions.
bioRxiv · Feb 23, 2023Pharmacology & Toxicology
R. W. Robey, C. M. Fitzsimmons, W. M. Guiblet, W. J. E. Frye, J. Gonzalez Dalmasy, L. Wang, D. A. Russell, L. M. Huff, A. J. Perciaccante, F. Ali-Rahmani, C. C. Lipsey, H. M. Wade, A. V. Mitchell, S. S. Maligireddy, D. Terrero, , P. J. Batista
This study identifies METTL7A and METTL7B as methyltransferases that confer resistance to thiol-based HDAC inhibitors by modifying the drug's zinc-binding thiol.
bioRxiv · Oct 7, 2022Cancer Biology
A. Basseville, P.-C. Violet, M. Safari, C. Sourbier, M. Linehan, R. W. Robey, M. Levine, D. L. Sackett, S. E. Bates
This study shows that the HDAC inhibitor romidepsin induces acetyl-CoA depletion and metabolic stress in KRAS-activated cells, linking HDACi sensitivity to acetyl-CoA metabolism pathways.
bioRxiv · Jan 31, 2022Cancer Biology
R. W. Robey, A. N. Robinson, F. Ali-Rahmani, L. M. Huff, S. Lusvarghi, S. Vahedi, J. M. Hotz, A. C. Warner, D. Butcher, J. Matta, E. F. Edmondson, T. D. Lee, J. S. Roth, O. W. Lee, M. Shen, , M. M. Gottesman
This study characterizes zebrafish homologs of the human ABCB1 gene, showing that abcb4 closely resembles P-gp in function and localization, while abcb5 differs.
bioRxiv · Feb 18, 2021Pharmacology & Toxicology
T. D. Lee, O. W. Lee, K. R. Brimacombe, L. Chen, R. Guha, S. Lusvarghi, B. G. Tebase, C. Klumpp-Thomas, R. W. Robey, S. V. Ambudkar, M. Shen, M. M. Gottesman, M. D. Hall
This paper identifies 90 P-gp substrates from 10,804 compounds using a high-throughput screen, including 55 new substrates confirmed by orthogonal assays.
bioRxiv · Jan 23, 2019Pharmacology & Toxicology
W. J. Wulftange, M. A. Rose, M. Garmendia-Cedillos, D. da Silva, J. E. Poprawski, D. Srinivasachar, T. Sullivan, L. Lim, V. V. Bliskovsky, M. D. Hall, T. J. Pohida, R. W. Robey, N. Y. Morgan, M. M. Gottesman
The paper compares cancer cell growth and gene expression in different oxygen environments, finding that controlled oxygen delivery in 3D cultures better mimics physiological conditions.
bioRxiv · Jan 18, 2019 · PreprintBioengineering