M. Safari

Modeling the impact of optimized airflow and sick pen management on the spread of infectious diseases in swine barns

This study models how optimized airflow and sick pen placement in swine barns affect disease spread, finding that ventilation adjustments and strategic pen placement can reduce disease transmission by up to 43.2%.

Histone deacetylase inhibitor induces acetyl-CoA depletion leading to lethal metabolic stress in RAS-pathway activated cells

This study shows that the HDAC inhibitor romidepsin induces acetyl-CoA depletion and metabolic stress in KRAS-activated cells, linking HDACi sensitivity to acetyl-CoA metabolism pathways.

Functional and Structural Segregation of Overlapping Helices in HIV-1

The paper investigates how overlapping genes in HIV-1 balance selective forces, finding functional segregation where each protein spaces its residues to accommodate the other's functional sites.

CK1 Delta Is an mRNA Cap-Associated Protein That Drives Translation Initiation and Tumor Growth

This paper identifies CK1 delta as an mRNA cap-associated protein that drives translation initiation and tumor growth in blood cancers, with distinct roles in solid tumors.

Mesoscopic Liquid Clusters Represent a Distinct Condensate of Mutant p53

This study investigates the phase behavior of mutant p53, showing it forms mesoscopic liquid clusters that facilitate amyloid fibril nucleation and revealing that structural destabilization drives condensation.