Author

M. Linehan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

A. Basseville· 1 shared A. Iwasaki· 1 shared A. M. Pyle· 1 shared B. Israelow· 1 shared B. L. Menasche· 1 shared C. A. Briney· 1 shared C. B. F. Vogels· 1 shared C. B. Wilen· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperCancer Biology

A. Basseville

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Histone deacetylase inhibitor induces acetyl-CoA depletion leading to lethal metabolic stress in RAS-pathway activated cells

A. Basseville, P.-C. Violet, M. Safari, C. Sourbier, M. Linehan, R. W. Robey, M. Levine, D. L. Sackett, S. E. Bates

This study shows that the HDAC inhibitor romidepsin induces acetyl-CoA depletion and metabolic stress in KRAS-activated cells, linking HDACi sensitivity to acetyl-CoA metabolism pathways.

bioRxiv · Jan 31, 2022Cancer Biology

A stem-loop RNA RIG-I agonist confers prophylactic and therapeutic protection against acute and chronic SARS-CoV-2 infection in mice

T. Mao, B. Israelow, C. Lucas, C. B. F. Vogels, O. Fedorova, M. I. Breban, B. L. Menasche, H. Dong, M. Linehan, Yale SARS-CoV-2 Genome Surveillance Initiative, C. B. Wilen, M. L. Landry, N. D. Grubaugh, A. M. Pyle, A. Iwasaki

This study shows that SLR14, a RIG-I agonist, prevents and treats SARS-CoV-2 infection in mice, including chronic cases and variants, through IFN-I responses.

bioRxiv · Jun 16, 2021Immunology

An Oncometabolite Isomer Rapidly Induces A Pathophysiological Protein Modification

S. E. Bergholtz, C. A. Briney, S. S. Najera, M. Perez, M. Linehan, J. L. Meier

This study develops chemical agonists to induce S-succination, a posttranslational modification linked to oncometabolites, and demonstrates their cellular effects.

bioRxiv · Jan 11, 2020Biochemistry