Author

D. L. Toffaletti

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:fungi (other)· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Bartesaghi· 1 shared A. L. Hsu· 1 shared E. J. Washington· 1 shared J. L. Tenor· 1 shared J. R. Perfect· 1 shared M. J. Borgnia· 1 shared M. Petrovich· 1 shared R. G. Brennan· 1 shared

Activity by Year

2023-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

A. Bartesaghi

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1 paper

Recent·Most cited

Structures of trehalose-6-phosphate synthase, Tps1, from the fungal pathogen Cryptococcus neoformans: a target for novel antifungals

E. J. Washington, Y. Zhou, A. L. Hsu, M. Petrovich, J. L. Tenor, D. L. Toffaletti, Z. Guan, J. R. Perfect, M. J. Borgnia, A. Bartesaghi, R. G. Brennan

This paper reports the cryo-EM structures of CnTps1 from Cryptococcus neoformans in unliganded and ligand-bound forms, revealing substrate-binding residues and tetramer stabilization, with implications for antifungal drug design.

bioRxiv · Mar 14, 2023 · PreprintBiochemistry