Author

A. L. Hsu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Immunology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Assay:structural biology· 3 Assay:cryo-EM· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Organism:virus· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

M. J. Borgnia· 6 shared A. Bartesaghi· 3 shared B. F. Haynes· 3 shared P. Acharya· 3 shared R. Henderson· 3 shared Y. Zhou· 3 shared K. Janowska· 2 shared K. Mansouri· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersBiochemistry

M. J. Borgnia

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Structures of trehalose-6-phosphate synthase, Tps1, from the fungal pathogen Cryptococcus neoformans: a target for novel antifungals

E. J. Washington, Y. Zhou, A. L. Hsu, M. Petrovich, J. L. Tenor, D. L. Toffaletti, Z. Guan, J. R. Perfect, M. J. Borgnia, A. Bartesaghi, R. G. Brennan

This paper reports the cryo-EM structures of CnTps1 from Cryptococcus neoformans in unliganded and ligand-bound forms, revealing substrate-binding residues and tetramer stabilization, with implications for antifungal drug design.

bioRxiv · Mar 14, 2023 · PreprintBiochemistry

Cryo-EM Structures of the SARS-CoV-2 Endoribonuclease Nsp15

M. C. Pillon, M. N. Frazier, L. Dillard, J. G. Williams, S. Kocaman, J. M. Krahn, L. Perera, C. K. Hayne, J. Gordon, Z. D. Stewart, M. Sobhany, L. J. Deterding, A. L. Hsu, V. P. Dandey, M. J. Borgnia, R. E. Stanley

This study determines the cryo-EM structures of SARS-CoV-2 Nsp15, revealing its active site interactions with uridine and conformational changes, which inform potential therapeutic targets.

bioRxiv · Aug 11, 2020 · PreprintBiochemistry

Fab-dimerized glycan-reactive antibodies neutralize HIV and are prevalent in humans and rhesus macaques

W. B. Williams, R. Meyerhoff, R. J. Edwards, H. Li, N. Nicely, R. Henderson, Y. Zhou, K. Janowska, K. Mansouri, K. Manne, V. Stalls, A. L. Hsu, M. J. Borgnia, G. Stewart-Jones, M. S. Lee, , B. F. Haynes

The paper identifies Fab-dimerized glycan-reactive antibodies in HIV-infected macaques and HIV-naïve humans that neutralize HIV-1 and can be elicited by vaccination.

bioRxiv · Jun 30, 2020 · PreprintImmunology

Controlling the SARS-CoV-2 Spike Glycoprotein Conformation

R. Henderson, R. J. Edwards, K. Mansouri, K. Janowska, V. Stalls, S. Gobeil, M. Kopp, A. L. Hsu, M. J. Borgnia, R. Parks, B. F. Haynes, P. Acharya

The paper analyzes SARS-CoV-2 spike protein conformations and develops engineered constructs to control its mobility for vaccine design.

bioRxiv · May 18, 2020Immunology

Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements

R. Henderson, M. Lu, Y. Zhou, Z. Mu, R. Parks, Q. Han, A. L. Hsu, E. Carter, S. C. Blanchard, R. Edwards, K. Wiehe, K. O. Saunders, M. J. Borgnia, A. Bartesaghi, W. Mothes, , S. M. Alam

This study identifies a critical role for W571 in HIV-1 Env allostery by showing mutations disrupting CD4-induced rearrangements and rendering Env insensitive to CD4 binding.

bioRxiv · Nov 2, 2019Biochemistry

Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes

L. Zubcevic, A. L. Hsu, M. J. Borgnia, S.-Y. Lee

This study uses cryo-EM to show that RTx induces two-fold symmetric conformations of TRPV2, with greater symmetry in nanodiscs than in amphipol.

bioRxiv · Feb 8, 2019Biophysics