Author

E. J. Washington

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Organism:fungi (other)· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Bartesaghi· 1 shared A. L. Hsu· 1 shared B. K. Cizubu· 1 shared C. M. Santos· 1 shared C.-Y. Chen· 1 shared D. A. Okonkwo· 1 shared D. L. Toffaletti· 1 shared G. Silva· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiochemistry

A. Bartesaghi

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2 papers

Recent·Most cited

Redox control of the deubiquitinating enzyme Ubp2 regulates translation during stress

C. M. Santos, B. K. Cizubu, D. A. Okonkwo, C.-Y. Chen, N. Maske, N. A. Snyder, V. Simoes, E. J. Washington, G. Silva

This study shows that Ubp2, a DUB, is redox-regulated during oxidative stress in yeast, controlling K63-ub chains on ribosomes and restoring translation post-stress.

bioRxiv · Apr 30, 2024Biochemistry

Structures of trehalose-6-phosphate synthase, Tps1, from the fungal pathogen Cryptococcus neoformans: a target for novel antifungals

E. J. Washington, Y. Zhou, A. L. Hsu, M. Petrovich, J. L. Tenor, D. L. Toffaletti, Z. Guan, J. R. Perfect, M. J. Borgnia, A. Bartesaghi, R. G. Brennan

This paper reports the cryo-EM structures of CnTps1 from Cryptococcus neoformans in unliganded and ligand-bound forms, revealing substrate-binding residues and tetramer stabilization, with implications for antifungal drug design.

bioRxiv · Mar 14, 2023 · PreprintBiochemistry