Negative regulation of uPAR activity by a GPI-specific phospholipase C
M. van Veen, E. Matas-Rico, K. van de Wetering, D. Leyton-Puig, K. M. Kedziora, N. Sidenius, K. Jalink, A. Perrakis, W. H. Moolenaar
This study identifies GDE3 as a GPI-specific phospholipase C that cleaves uPAR, reducing its proteolytic and non-proteolytic activities and altering cell behavior in breast cancer.
bioRxiv · Dec 20, 2016Cell Biology