K. M. Kedziora

This study shows that chemotherapy-induced senescence-associated secretome promotes metastasis in ovarian cancer by reprogramming metabolism and increasing cell detachment.

This study shows ATR enhances mTORC1 activity through cholesterol synthesis via LSS, independent of CHK1 and TSC, and this effect is amplified in p16-deficient cells.

This study identifies the AKT2/SIRT5/TFEB pathway as a therapeutic target for atrophic AMD by showing its role in lysosomal dysfunction and drusen formation in RPE cells.

This study shows that combining vancomycin with unsaturated fatty acids enhances killing of S. aureus by promoting lipid II accumulation and membrane disruption.

This study maps the molecular architecture of cell cycle arrest by analyzing 49 effectors, identifying stress-specific arrest states and mechanisms, and showing convergence onto a senescent state with a G1-like signature.

This study examines how mammalian cells adapt to chronic cyclin E overproduction, revealing that adaptation involves downregulation of G1-regulated genes and partial resistance to replication stress.

The paper uses single-cell imaging and manifold learning to reveal alternative cell cycle paths and mechanisms of exit and re-entry in human cells.

The paper introduces PIP-FUCCI, a new reporter system for precise detection of S phase onset, revealing that APCCdh1 inactivation is not strictly required for S phase entry.

This study identifies RhoA-mDia2 signaling and Profilin-1 binding as regulators of CLIC4 translocation, which modulates filopodia length through actin dynamics.

This study identifies GDE3 as a GPI-specific phospholipase C that cleaves uPAR, reducing its proteolytic and non-proteolytic activities and altering cell behavior in breast cancer.