Author

W. H. Moolenaar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Perrakis· 4 shared E. Matas-Rico· 2 shared F. Salgado-Polo· 2 shared K. Jalink· 2 shared K. M. Kedziora· 2 shared A. J. Morris· 1 shared A. Mazzocca· 1 shared A. Menegakis· 1 shared

Activity by Year

2016-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersCell Biology

A. Perrakis

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Author profile →

4 papers

Recent·Most cited

Autotaxin facilitates selective LPA receptor signaling

F. Salgado-Polo, R. Borza, F. Marsais, C. Jagerschmidt, L. Waeckel, W. H. Moolenaar, P. Ford, B. Heckmann, A. Perrakis

This study shows that ATX inhibitors targeting the ATX tunnel selectively block LPA signaling via P2Y receptors, with implications for pulmonary fibrosis treatment.

bioRxiv · Apr 9, 2022Cell Biology

Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells

E. Matas-Rico, E. Frijlink, I. van der Haar Avila, A. Menegakis, M. van Zon, A. J. Morris, J. Koster, F. Salgado-Polo, S. de Kivit, T. Lanca, A. Mazzocca, Z. Johnson, J. Haanen, T. N. Schumacher, A. Perrakis, , W. H. Moolenaar

This study shows that ATX secreted by melanoma cells repels CD8+ T cells, reducing their infiltration into tumors and impairing anti-tumor immunity.

bioRxiv · Feb 26, 2020Cancer Biology

CLIC4 is regulated by RhoA-mDia2 signaling through Profilin-1 binding to modulate filopodia length

E. Argenzio, K. M. Kedziora, L. Nahidiazar, T. Isogai, A. Perrakis, K. Jalink, W. H. Moolenaar, M. Innocenti

This study identifies RhoA-mDia2 signaling and Profilin-1 binding as regulators of CLIC4 translocation, which modulates filopodia length through actin dynamics.

bioRxiv · Feb 2, 2018Cell Biology

Negative regulation of uPAR activity by a GPI-specific phospholipase C

M. van Veen, E. Matas-Rico, K. van de Wetering, D. Leyton-Puig, K. M. Kedziora, N. Sidenius, K. Jalink, A. Perrakis, W. H. Moolenaar

This study identifies GDE3 as a GPI-specific phospholipase C that cleaves uPAR, reducing its proteolytic and non-proteolytic activities and altering cell behavior in breast cancer.

bioRxiv · Dec 20, 2016Cell Biology