Author

D. M. Gay

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

O. J. Sansom· 3 shared R. A. Ridgway· 3 shared K. Gilroy· 2 shared N. Vlahov· 2 shared A. Burton· 1 shared A. D. Campbell· 1 shared A. Dexter· 1 shared A. E. Willis· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersCancer Biology

O. J. Sansom

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Author profile →

3 papers

Recent·Most cited

Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target

J. Vande Voorde, A. K. Najumudeen, R. T. Steven, C. J. Nikula, A. Dexter, L. B. Zeiger, E. A. Elia, A. Nassif, A. Gonzalez-Fernandez, T. Murta, M. Gillespie, C. A. Ford, T. R. M. Lannagan, N. Vlahov, R. A. Ridgway, , O. J. Sansom

This study uses metabolomics to stratify colorectal cancer tissues and identifies adenosylhomocysteinase as a potential therapeutic target.

bioRxiv · Mar 12, 2023Cancer Biology

β-catenin obstructs γδ T cell immunosurveillance in colon cancer through loss of BTNL expression

T. Suzuki, A. Kilbey, R. A. Ridgway, H. Hayman, R. Byrne, N. Casa Rodriguez, A. Georgakopoulou, L. Chen, M. Verzi, D. M. Gay, E. G. Vzquez, H. L. Belnoue-Davis, K. Gilroy, A. H. Kostner, C. Kersten, , S. B. Coffelt

This study shows that β-catenin signaling in colon cancer cells reduces BTNL expression, impairing γδ T cell immunosurveillance and promoting tumor progression.

bioRxiv · Jun 10, 2022 · PreprintCancer Biology

Rpl24Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K

J. R. Knight, N. Vlahov, D. M. Gay, R. A. Ridgway, L. Faller, C. Proud, G. R. Mallucci, T. von der Haar, C. M. Smales, A. E. Willis, O. J. Sansom

The paper shows that Rpl24Bst mutation suppresses colorectal cancer by enhancing eEF2 phosphorylation through eEF2K, reducing protein synthesis and tumorigenesis.

bioRxiv · May 5, 2021Cancer Biology