Author

R. Byrne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2 Approach:experimental assay· 1

Frequent Co-Authors

O. J. Sansom· 3 shared B. Ahmaderaghi· 2 shared K. Gilroy· 2 shared M. Lawler· 2 shared N. C. Fisher· 2 shared P. D. Dunne· 2 shared R. Amirkhah· 2 shared S. Corry· 2 shared

Activity by Year

2022-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersCancer Biology

O. J. Sansom

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Author profile →

3 papers

Recent·Most cited

MmCMS: Mouse models' Consensus Molecular Subtypes of colorectal cancer

R. Amirkhah, K. Gilroy, S. Malla, T. Lannagan, R. Byrne, N. C. Fisher, S. Corry, H. Naderi-Meshkin, B. Ahmaderaghi, R. Murray, M. Mills, A. Campbell, ACRCelerate consortium, A. Berenguer Llergo, R. Sanz-Pamplona, , P. Dunne

The paper develops three methods to classify mouse colorectal cancer models into human CMS subtypes, finding that pathway-level classifiers outperform gene-level ones for accurate subtype identification.

bioRxiv · Jun 17, 2022Cancer Biology

β-catenin obstructs γδ T cell immunosurveillance in colon cancer through loss of BTNL expression

T. Suzuki, A. Kilbey, R. A. Ridgway, H. Hayman, R. Byrne, N. Casa Rodriguez, A. Georgakopoulou, L. Chen, M. Verzi, D. M. Gay, E. G. Vzquez, H. L. Belnoue-Davis, K. Gilroy, A. H. Kostner, C. Kersten, , S. B. Coffelt

This study shows that β-catenin signaling in colon cancer cells reduces BTNL expression, impairing γδ T cell immunosurveillance and promoting tumor progression.

bioRxiv · Jun 10, 2022 · PreprintCancer Biology

Biological misinterpretation of transcriptional signatures in tumour samples can unknowingly undermine mechanistic understanding and faithful alignment with preclinical data

N. C. Fisher, R. Byrne, H. Leslie, C. Wood, A. Legrini, A. Cameron, B. Ahmaderaghi, S. Corry, S. Malla, R. Amirkhah, A. McCooey, E. Rogan, K. Redmond, S. Sakhnevych, E. Domingo, , P. D. Dunne

The paper shows that transcriptional signatures in tumour samples can be misinterpreted due to stromal influences, affecting alignment with preclinical data.

bioRxiv · Apr 15, 2022 · PreprintCancer Biology