Author

A. Kilbey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 4 Cancer Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:mouse· 6 Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Assay:bulk RNA-seq· 3 Research Focus:cell signaling & trafficking· 3 Research Focus:differential expression· 3 Approach:statistical model· 3 Research Focus:cancer & tumor microenvironment· 2

Frequent Co-Authors

S. B. Coffelt· 6 shared K. Blyth· 5 shared R. Wiesheu· 4 shared A. Hedley· 3 shared S. C. Edwards· 3 shared C. Miller· 2 shared J.-J. Fournie· 2 shared K. Kirschner· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

6 shared papersImmunology

S. B. Coffelt

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

IL-27 maintains cytotoxic Ly6C+ gamma delta T cells that arise from immature precursors

R. Wiesheu, S. C. Edwards, A. Hedley, M. Tosolini, M. G. F. Fares da Silva, N. Sumaria, Y. Optaczy, D. G. Hill, A. J. Hayes, J. Hay, A. Kilbey, A. M. Michie, G. Graham, A. Manoharan, C. Halsey, , S. B. Coffelt

The paper identifies immature and mature subsets of IFNγ-producing γδ T cells, showing IL-27 supports cytotoxic function in mature cells but not immature ones.

bioRxiv · Oct 26, 2023Immunology

Specialized Tfh cell subsets driving type-1 and type-2 humoral responses in lymphoid tissue

S. Kumar, A. Basto, F. Ribeiro, S. S. C. P. Almeida, P. Campos, C. Peres, S. Al-Khalidi, A. Kilbey, J. Tosello, E. Piaggio, M. Russo, M. Gama-Carvalho, S. B. Coffelt, E. W. Roberts, H. Florindo, L. Graca

The paper identifies specialized Tfh1 and Tfh2 subsets driving type-1 and type-2 humoral responses using single-cell transcriptomics and machine learning.

bioRxiv · Jul 28, 2022Immunology

β-catenin obstructs γδ T cell immunosurveillance in colon cancer through loss of BTNL expression

T. Suzuki, A. Kilbey, R. A. Ridgway, H. Hayman, R. Byrne, N. Casa Rodriguez, A. Georgakopoulou, L. Chen, M. Verzi, D. M. Gay, E. G. Vzquez, H. L. Belnoue-Davis, K. Gilroy, A. H. Kostner, C. Kersten, , S. B. Coffelt

This study shows that β-catenin signaling in colon cancer cells reduces BTNL expression, impairing γδ T cell immunosurveillance and promoting tumor progression.

bioRxiv · Jun 10, 2022 · PreprintCancer Biology

Single-cell analysis uncovers differential regulation of lung γδ T cell subsets by the co-inhibitory molecules, PD-1 and TIM-3

S. C. Edwards, A. Hedley, W. H. M. Hoevenaar, T. Glauner, R. Wiesheu, A. Kilbey, R. Shaw, K. Boufea, N. Batada, K. Blyth, C. Miller, K. Kirschner, S. B. Coffelt

This study identifies differential regulation of lung γδ T cell subsets by PD-1 and TIM-3 using single-cell RNA sequencing and flow cytometry.

bioRxiv · Jul 4, 2021Immunology

Ly6C defines a subset of memory-like CD27+ γδ T cells with inducible cancer-killing function

R. Wiesheu, S. C. Edwards, A. Hedley, K. Kirschner, M. Tosolini, J.-J. Fournie, A. Kilbey, S.-J. Remak, C. Miller, K. Blyth, S. B. Coffelt

The paper identifies two subsets of CD27+ γδ T cells in mice, distinguished by Ly6C expression, with one subset showing memory-like properties and cancer-killing potential.

bioRxiv · Sep 8, 2020 · PreprintImmunology

The MSP-RON axis stimulates cancer cell growth in models of triple negative breast cancer

R. Millar, A. Kilbey, S.-J. Remak, T. M. Severson, S. Dhayade, E. Sandilands, K. Foster, D. M. Bryant, K. Blyth, S. B. Coffelt

This study identifies the MSP-RON axis as a driver of TNBC growth in a mouse model and shows that inhibiting RON reduces tumor progression.

bioRxiv · Feb 19, 2020Cancer Biology