Author

D. Melchers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 1 Assay:proteomics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

E. A. Ortlund· 2 shared E. H. D'Agostino· 2 shared J. L. Cornelison· 2 shared M. L. Cato· 2 shared N. T. Jui· 2 shared R. Houtman· 2 shared S. G. Mays· 2 shared A. B. Patel· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersBiochemistry

E. A. Ortlund

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Tapping into a phospholipid-LRH-1 axis yields a powerful anti-inflammatory agent with in vivo activity against colitis

S. G. Mays, E. H. D'Agostino, A. R. Flynn, X. Huang, G. Wang, X. Liu, E. J. Millings, C. D. Okafor, A. Patel, M. L. Cato, J. L. Cornelison, D. Melchers, R. Houtman, D. D. Moore, J. W. Calvert, , E. A. Ortlund

The paper develops a phospholipid-mimicking LRH-1 agonist that shows in vivo efficacy in a colitis model by improving binding affinity and transcriptional activity.

bioRxiv · Sep 1, 2020 · PreprintBiochemistry

Development of a new class of liver receptor homolog-1 (LRH-1) agonists by photoredox conjugate addition

J. L. Cornelison, M. L. Cato, A. M. Johnson, E. H. D'Agostino, D. Melchers, A. B. Patel, S. G. Mays, R. Houtman, E. A. Ortlund, N. T. Jui

This study develops a new class of LRH-1 agonists using a photoredox conjugate addition method, enabling bridgehead substitution to enhance ligand activation.

bioRxiv · Mar 16, 2020Biochemistry