Author

D. D. Moore

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Physiology· 2 Animal Behavior & Cognition· 1 Biochemistry· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 7 Research Focus:host-pathogen & immune response· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2

Frequent Co-Authors

B. Dong· 3 shared Z. Sun· 3 shared C. Coarfa· 2 shared G. Wang· 2 shared H. Wang· 2 shared X. Huang· 2 shared A. Eliason· 1 shared A. Patel· 1 shared

Activity by Year

2018-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersCancer Biology

B. Dong

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Accumulation of auranofin in white adipose tissues lowers leptin levels and exerts anti-diabetic effects

A. R. Cox, P. M. Masschelin, P. Saha, J. B. Felix, R. Sharp, Z. Lian, Y. Xia, N. Chernis, D. A. Bader, K. H. Kim, X. Li, J. Yoshino, X. Li, Z. Sun, H. Wu, , S. M. Hartig

The paper identifies auranofin as a drug that lowers leptin levels in white adipose tissue and improves insulin sensitivity in obese mice, with anti-diabetic effects.

bioRxiv · Sep 11, 2021 · PreprintPhysiology

Validating marker-less pose estimation with 3D x-ray radiography

D. D. Moore, J. D. Walker, J. N. MacLean, N. G. Hatsopoulos

The paper validates DeepLabCut's accuracy using 3D x-ray radiography, showing low median error in tracking marmoset limb and torso movements.

bioRxiv · Jun 15, 2021Animal Behavior & Cognition

LRH-1 NUTRIGENOMICS: The Provision of Lauric Acid Results in the Endogenous Production of the Liver Receptor Homolog-1 Ligand, Dilauroylphosphatidylcholine, and LRH-1 Transactivation

K. C. Klatt, S. Zhang, O. V. Malysheva, Z. Sun, B. Dong, J. T. Brenna, D. D. Moore, M. S. Roberson, M. A. Caudill

This study shows that lauric acid intake leads to endogenous production of DLPC, an LRH-1 ligand, and enhances LRH-1 transcriptional activity in multiple tissues.

bioRxiv · Feb 1, 2021 · PreprintPhysiology

Oncogenic Activation of AKT by MAPK6

Q. Cai, W. Wang, B. Dong, W. Zhou, T. Shen, D. D. Moore, C. J. Creighton, F. Yang

This study shows that MAPK6 activates AKT to promote cancer, leading to oncogenic outcomes and poor patient survival in multiple cancers.

bioRxiv · Sep 23, 2020Cancer Biology

Tapping into a phospholipid-LRH-1 axis yields a powerful anti-inflammatory agent with in vivo activity against colitis

S. G. Mays, E. H. D'Agostino, A. R. Flynn, X. Huang, G. Wang, X. Liu, E. J. Millings, C. D. Okafor, A. Patel, M. L. Cato, J. L. Cornelison, D. Melchers, R. Houtman, D. D. Moore, J. W. Calvert, , E. A. Ortlund

The paper develops a phospholipid-mimicking LRH-1 agonist that shows in vivo efficacy in a colitis model by improving binding affinity and transcriptional activity.

bioRxiv · Sep 1, 2020 · PreprintBiochemistry

Constitutive Androstane Receptor and Hepatitis B Virus X Protein Cooperatively Induce β-catenin-Activated Liver Tumors

J. Scott, S. Liu, K. Klatt, Z. Sun, Q. Guo, S. Grimm, C. Coarfa, B. Dong, D. D. Moore

This study shows that activating CAR with HBx in mice leads to liver tumors with strong β-catenin activation, mirroring human HBV-related HCC.

bioRxiv · Aug 8, 2020 · PreprintCancer Biology

CAR/Nr1i3 directs T cell adaptation to bile acids in the small intestine

M. L. Chen, X. Huang, H. Wang, Y. Liu, J. Shang, A. Eliason, C. Hegner, H. Park, B. Frey, G. Wang, D. J. Kojetin, C. T. Weaver, M. E. Pipkin, D. D. Moore, M. S. Sundrud

This study identifies CAR/Nr1i3 as a regulator of T cell adaptation to bile acids in the small intestine, showing its role in detoxification and inflammation resolution.

bioRxiv · Jul 30, 2020 · PreprintImmunology

LRH-1 Mitigates Intestinal Inflammatory Disease by Maintaining Epithelial Homeostasis and Cell Survival

J. R. Bayrer, H. Wang, R. Nattiv, M. Suzawa, H. S. Escusa, R. J. Fletterick, O. D. Klein, D. D. Moore, H. A. Ingraham

This study shows that LRH-1 maintains intestinal epithelial homeostasis and cell survival, and its overexpression mitigates inflammatory damage in IBD models.

bioRxiv · May 22, 2018Cell Biology