Author

A. R. Flynn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Organism:human· 1 Organism:mouse· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

C. D. Okafor· 2 shared E. A. Ortlund· 2 shared E. J. Millings· 2 shared G. Wang· 2 shared S. G. Mays· 2 shared X. Huang· 2 shared A. Patel· 1 shared D. D. Moore· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersBiochemistry

C. D. Okafor

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Author profile →

2 papers

Recent·Most cited

Tapping into a phospholipid-LRH-1 axis yields a powerful anti-inflammatory agent with in vivo activity against colitis

S. G. Mays, E. H. D'Agostino, A. R. Flynn, X. Huang, G. Wang, X. Liu, E. J. Millings, C. D. Okafor, A. Patel, M. L. Cato, J. L. Cornelison, D. Melchers, R. Houtman, D. D. Moore, J. W. Calvert, , E. A. Ortlund

The paper develops a phospholipid-mimicking LRH-1 agonist that shows in vivo efficacy in a colitis model by improving binding affinity and transcriptional activity.

bioRxiv · Sep 1, 2020 · PreprintBiochemistry

Development of the first low nanomolar Liver Receptor Homolog-1 agonist through structure-guided design

S. G. Mays, A. R. Flynn, J. L. Corneilson, C. D. Okafor, H. Wang, G. Wang, X. Huang, H. N. Donaldson, E. J. Millings, R. Polavarapu, D. Moore, J. Calvert, N. Jui, E. A. Ortlund

This study develops the first low nanomolar LRH-1 agonist using structure-guided design, showing increased potency and anti-inflammatory effects in an organoid model.

bioRxiv · May 17, 2019Pharmacology & Toxicology