Author

D. Merk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:protein structure· 1 Assay:structural biology· 1 Organism:virus· 1

Frequent Co-Authors

A. Chaikuad· 2 shared S. Knapp· 2 shared D. Heidenreich· 1 shared E. Proschak· 1 shared J. Schmidt· 1 shared M. E. Sharpe· 1 shared M. Moustakim· 1 shared M. Schroeder· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

A. Chaikuad

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2 papers

Recent·Most cited

Structural insights into plasticity and discovery of remdesivir metabolite GS-441524 binding in SARS-CoV-2 macrodomain

X. Ni, M. Schroeder, V. Olieric, M. E. Sharpe, V. Olmos, E. Proschak, D. Merk, S. Knapp, A. Chaikuad

The paper reports crystal structures of SARS-CoV-2 nsP3 macrodomain bound to nucleotides and remdesivir metabolites, revealing structural plasticity and potential inhibitor targets.

bioRxiv · Mar 4, 2021Biochemistry

A structure-based approach towards identification of inhibitory fragments for eleven-nineteen-leukemia protein (ENL) YEATS domain

D. Heidenreich, M. Moustakim, J. Schmidt, D. Merk, P. E. Brennan, O. Fedorov, A. Chaikuad, S. Knapp

The paper identifies inhibitory fragments targeting the ENL YEATS domain using crystallography, providing starting points for chemical probe development.

bioRxiv · Nov 8, 2018Biochemistry