Author

D. Heidenreich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

O. Fedorov· 3 shared S. Knapp· 3 shared A. Chaikuad· 2 shared M. Moustakim· 2 shared P. E. Brennan· 2 shared C. H. Arrowsmith· 1 shared D. Merk· 1 shared G. Deblois· 1 shared

Activity by Year

2018-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersBiochemistry

O. Fedorov

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Author profile →

3 papers

Recent·Most cited

Structural insights into interaction mechanisms of alternative piperazine-urea YEATS domain binders in MLLT1

X. Ni, D. Heidenreich, T. Christott, J. Bennett, M. Moustakim, P. Brennan, O. Fedorov, S. Knapp, A. Chaikuad

The paper characterizes piperazine-urea derivatives as acetyl/acyl-lysine mimetics for MLLT1 and reveals distinct interaction mechanisms through crystal structures.

bioRxiv · Nov 9, 2019Biochemistry

A structure-based approach towards identification of inhibitory fragments for eleven-nineteen-leukemia protein (ENL) YEATS domain

D. Heidenreich, M. Moustakim, J. Schmidt, D. Merk, P. E. Brennan, O. Fedorov, A. Chaikuad, S. Knapp

The paper identifies inhibitory fragments targeting the ENL YEATS domain using crystallography, providing starting points for chemical probe development.

bioRxiv · Nov 8, 2018Biochemistry

A Chemical Toolbox for the Study of Bromodomains and Epigenetic Signaling

Q. Wu, D. Heidenreich, S. Zhou, S. Ackloo, G. Deblois, S. Duan, K. Nakka, J. Dilworth, M. Lupien, P. E. Brennan, C. H. Arrowsmith, S. Mueller, O. Fedorov, P. Filippakopoulos, S. Knapp

The paper presents a set of 25 chemical probes targeting human bromodomains and demonstrates their utility in studying muscle cell differentiation and triple negative breast cancer.

bioRxiv · Aug 14, 2018Cell Biology