Osteoclasts contribute to early development of chronic inflammation by promoting dysregulated hematopoiesis and myeloid skewing
M.-B. Madel, L. Ibanez, T. Ciucci, J. Halper, M. Topi, H.-J. Garchon, M. Rouleau, C. G. Mueller, L. Peyrin Biroulet, D. MOULIN, C. Blin-Wakkach, A. Wakkach
This study shows osteoclasts drive myeloid skewing and inflammation in chronic colitis by altering HSC niche interactions and promoting myelopoiesis.
bioRxiv · Dec 9, 2020 · PreprintImmunology