T. Ciucci

Specific targeting of inflammatory osteoclastogenesis by the probiotic yeast S. boulardii CNCM I-745 reduces bone loss in osteoporosis

This study identifies PRRs regulating inflammatory osteoclasts and shows that S. boulardii reduces bone loss by targeting these cells.

A single-cell reference atlas delineates CD4+ T cell subtype-specific adaptation during acute and chronic viral infections

This study constructs a single-cell reference atlas of CD4+ T cell states during acute and chronic viral infections, identifying six distinct transcriptional states and their dynamics.

SARS coronavirus vaccines protect against different coronaviruses

This study shows SARS-CoV-2 vaccines and prior coronavirus infections generate cross-reactive antibodies and T cell responses that provide protection against other coronaviruses in humans and mice.

Limiting the priming dose of a SARS CoV-2 vaccine improves virus-specific immunity

This study shows that reducing the priming dose of a SARS-CoV-2 vaccine can lead to stronger immune responses after boosting, suggesting potential benefits for vaccine distribution and design.

Osteoclasts contribute to early development of chronic inflammation by promoting dysregulated hematopoiesis and myeloid skewing

This study shows osteoclasts drive myeloid skewing and inflammation in chronic colitis by altering HSC niche interactions and promoting myelopoiesis.

Single-cell profiling of tumor-reactive CD4+ T-cells reveals unexpected transcriptomic diversity

The paper uses single-cell RNA sequencing to reveal diverse transcriptomic patterns in CD4+ T cells responding to tumors, highlighting differences from virus responses and potential implications for immunotherapy.