Microneedle-mediated intratumoral delivery of anti-CTLA-4 promotes cDC1-dependent eradication of oral squamous cell carcinoma with limited irAEs
M. Gilardi, R. Saddawi-Konefka, V. H. Wu, M. A. Lopez-Ramirez, Z. Wang, F. Soto, D. J. Steffen, M. Proietto, Z. Mikulski, H. Miki, A. Sharabi, D. Kupor, R. Rueda, D. P. Hollern, J. Wang, J. S. Gutkind
This study demonstrates that microneedle-mediated local delivery of anti-CTLA-4 antibody reduces immune-related adverse events while effectively treating oral squamous cell carcinoma.
bioRxiv · Dec 7, 2021Cancer Biology