Author

V. H. Wu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

J. S. Gutkind· 4 shared Z. Wang· 3 shared A. A. Molinolo· 2 shared A. Sharabi· 2 shared E. E. W. Cohen· 2 shared J. P. Mesirov· 2 shared M. Gilardi· 2 shared M. M. Allevato· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersCancer Biology

J. S. Gutkind

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Author profile →

5 papers

Recent·Most cited

Profound phenotypic and epigenetic heterogeneity of the HIV-1 infected CD4+ T cell reservoir

V. H. Wu, S. Nguyen, J. M. L. Nordin, J. Joy, F. Mampe, P. Tebas, L. J. Montaner, K. J. Bar, L. A. Vella, M. R. Betts

This study identifies phenotypic and epigenetic heterogeneity in the HIV-1 infected CD4+ T cell reservoir using single-cell multiomic profiling of ART-treated individuals.

bioRxiv · Apr 2, 2022Microbiology

Lymphatic-Preserving Treatment Sequencing with Immune Checkpoint Inhibition Unleashes cDC1-Dependent Antitumor Immunity in HNSCC

R. Saddawi-Konefka, A. O'Farrell, F. Faraji, L. Clubb, M. M. Allevato, N.-A. A. S. Anang, S. M. Jensen, Z. Wang, V. H. Wu, B. S. Yung, R. Al Msari, I. Franiak Pietryga, A. A. Molinolo, J. P. Mesirov, A. B. Simon, , J. S. Gutkind

This study shows that lymphatic-preserving treatment sequences enhance cDC1-dependent antitumor immunity in HNSCC by avoiding lymphablation, which compromises ICI response.

bioRxiv · Feb 1, 2022Cancer Biology

Microneedle-mediated intratumoral delivery of anti-CTLA-4 promotes cDC1-dependent eradication of oral squamous cell carcinoma with limited irAEs

M. Gilardi, R. Saddawi-Konefka, V. H. Wu, M. A. Lopez-Ramirez, Z. Wang, F. Soto, D. J. Steffen, M. Proietto, Z. Mikulski, H. Miki, A. Sharabi, D. Kupor, R. Rueda, D. P. Hollern, J. Wang, J. S. Gutkind

This study demonstrates that microneedle-mediated local delivery of anti-CTLA-4 antibody reduces immune-related adverse events while effectively treating oral squamous cell carcinoma.

bioRxiv · Dec 7, 2021Cancer Biology

Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response

M. Pagadala, V. H. Wu, E. Perez-Guijarro, H. Kim, A. Castro, J. Talwar, T. Sears, C. Gonzalez-Colin, S. Cao, B. Schmiedel, S. Goudarzi, D. Kirani, R. Salem, G. Morris, O. Harismendy, , H. Carter

The paper identifies germline variants associated with the tumor immune microenvironment, linking them to cancer risk and immunotherapy response.

bioRxiv · Apr 14, 2021 · PreprintCancer Biology

Novel syngeneic animal model of tobacco-associated oral cancer reveals the activity of in situ anti-CTLA-4

Z. Wang, V. H. Wu, M. M. Allevato, M. Gilardi, Y. He, J. L. Callejas-Valera, L. Vitale-Cross, D. Martin, P. Amornphimoltham, J. Mcdermott, Y. Goto, A. A. Molinolo, A. B. Sharabi, E. E. W. Cohen, Q. Chen, , J. S. Gutkind

This paper develops a syngeneic mouse model of tobacco-associated HNSCC that shows high response rates to anti-CTLA-4 therapy.

bioRxiv · Jun 15, 2019 · PreprintCancer Biology