Author

D. Royston

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Assay:imaging· 1

Frequent Co-Authors

B. Psaila· 3 shared N. Sousos· 3 shared A. Mead· 2 shared G. Wang· 2 shared J. O'Sullivan· 2 shared K. Sirinukunwattana· 2 shared R. Li· 2 shared S. Thongjuea· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersCancer Biology

B. Psaila

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A pro-inflammatory stem cell niche drives myelofibrosis through a targetable galectin 1 axis

R. Li, M. Colombo, G. Wang, A. Rodriguez-Romera, J. O'Sullivan, S.-A. Clark, J. Perez Saez, Y. Meng, A. Khan, S. Wen, P. Dong, W. Zhou, N. Sousos, L. Murphy, M. Clarke, , B. Psaila

This study identifies a pro-inflammatory stem cell niche that drives myelofibrosis via galectin 1, offering a targetable pathway for therapy.

bioRxiv · Aug 5, 2023 · PreprintCancer Biology

Improving the diagnosis and classification of Ph-negative myeloproliferative neoplasms through deep phenotyping

K. Sirinukunwattana, A. Aberdeen, H. Theissen, N. Sousos, B. Psaila, A. Mead, G. Turner, G. Rees, J. Rittscher, D. Royston

This paper develops a machine-learning approach to automate megakaryocyte morphology analysis in bone marrow trephine samples to improve diagnosis of Ph-negative myeloproliferative neoplasms.

bioRxiv · Sep 11, 2019 · PreprintPathology

Single-cell analyses reveal aberrant pathways for megakaryocyte-biased hematopoiesis in myelofibrosis and identify mutant clone-specific targets

B. Psaila, G. Wang, A. Rodriguez Meira, E. F. Heuston, R. Li, J. O'Sullivan, N. Sousos, S. Anderson, Y. Senis, O. Weinberg, M. L. Callicchio, NIH Intramural Sequencing Core, D. Iskander, D. Royston, D. Milojkovic, , A. J. Mead

The paper uses single-cell multi-omics to identify aberrant megakaryocyte pathways in myelofibrosis and discovers JAK2-mutant-specific targets for immunotherapy.

bioRxiv · May 20, 2019Cancer Biology