B. Psaila

HIF-1 activated by PIM1 assembles a pathological transcription complex and regulon that drives JAK2V617F MPN disease

This study identifies that HIF-1 activation by PIM1 in JAK2V617F-MPNs drives non-canonical transcription complex formation and disease progression.

Chromothripsis orchestrates leukemic transformation in blast phase MPN through targetable amplification of DYRK1A

The paper identifies chromothripsis-induced amplification of DYRK1A in blast phase MPN as a driver of aggressive disease and a potential therapeutic target.

A pro-inflammatory stem cell niche drives myelofibrosis through a targetable galectin 1 axis

This study identifies a pro-inflammatory stem cell niche that drives myelofibrosis via galectin 1, offering a targetable pathway for therapy.

Deciphering TP53 mutant Cancer Evolution with Single-Cell Multi-Omics

The paper uses single-cell multi-omic analysis to study TP53-mutant cancer evolution in leukaemia, identifying a role for chronic inflammation in promoting TP53 mutant clones.

Human bone marrow organoids for disease modelling, discovery and validation of therapeutic targets in hematological malignancies

This paper develops human bone marrow organoids to model hematological malignancies and validate therapeutic targets.

Improving the diagnosis and classification of Ph-negative myeloproliferative neoplasms through deep phenotyping

This paper develops a machine-learning approach to automate megakaryocyte morphology analysis in bone marrow trephine samples to improve diagnosis of Ph-negative myeloproliferative neoplasms.

Single-cell analyses reveal aberrant pathways for megakaryocyte-biased hematopoiesis in myelofibrosis and identify mutant clone-specific targets

The paper uses single-cell multi-omics to identify aberrant megakaryocyte pathways in myelofibrosis and discovers JAK2-mutant-specific targets for immunotherapy.