N. Sousos

A pro-inflammatory stem cell niche drives myelofibrosis through a targetable galectin 1 axis

This study identifies a pro-inflammatory stem cell niche that drives myelofibrosis via galectin 1, offering a targetable pathway for therapy.

Deciphering TP53 mutant Cancer Evolution with Single-Cell Multi-Omics

The paper uses single-cell multi-omic analysis to study TP53-mutant cancer evolution in leukaemia, identifying a role for chronic inflammation in promoting TP53 mutant clones.

Improving the diagnosis and classification of Ph-negative myeloproliferative neoplasms through deep phenotyping

This paper develops a machine-learning approach to automate megakaryocyte morphology analysis in bone marrow trephine samples to improve diagnosis of Ph-negative myeloproliferative neoplasms.

Single-cell analyses reveal aberrant pathways for megakaryocyte-biased hematopoiesis in myelofibrosis and identify mutant clone-specific targets

The paper uses single-cell multi-omics to identify aberrant megakaryocyte pathways in myelofibrosis and discovers JAK2-mutant-specific targets for immunotherapy.

Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia

This study identifies heterogeneous leukemia stem cells in JMML using single-cell RNA-sequencing and clonogenic assays, revealing their molecular features and potential therapeutic targets.