Author

A. J. Mead

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 6

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 6 Approach:experimental assay· 6 Organism:human· 6 Research Focus:differential expression· 5 Assay:bulk RNA-seq· 3 Research Focus:cell-cell communication· 3 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2

Frequent Co-Authors

A. Rodriguez-Meira· 3 shared B. Psaila· 3 shared S. Thongjuea· 3 shared A. Hamblin· 2 shared C. Harrison· 2 shared E. Papaemmanuil· 2 shared G. Wang· 2 shared I. Antony-Debre· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersCancer Biology

A. Rodriguez-Meira

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Author profile →

6 papers

Recent·Most cited

Chromothripsis orchestrates leukemic transformation in blast phase MPN through targetable amplification of DYRK1A

C. K. Brierley, B. H. Yip, G. Orlando, H. Goyal, S. Wen, J. Wen, M. F. Levine, M. G. Jakobsdottir, A. Rodriguez-Meira, A. Adamo, M. Bashton, A. Hamblin, S. A. Clark, J. O'Sullivan, L. Murphi, , A. J. Mead

The paper identifies chromothripsis-induced amplification of DYRK1A in blast phase MPN as a driver of aggressive disease and a potential therapeutic target.

bioRxiv · Dec 8, 2023 · PreprintCancer Biology

Erythroid differentiation intensifies RNA mis-splicing in SF3B1-mutant myelodysplastic syndromes with ring sideroblasts

P. L. Moura, T. Mortera-Blanco, I. J. F. Hofman, G. Todisco, W. W. Kretzschmar, A.-C. Bjorklund, M. Creignou, M. Hagemann-Jensen, C. Ziegenhain, D. C. Granados, I. Barbosa, G. Walldin, M. Jansson, N. Ashley, A. J. Mead, , E. Hellstrom-Lindberg

This study investigates SF3B1-mutant myelodysplastic syndromes with ring sideroblasts by isolating RS and analyzing their development and mis-splicing during erythroid differentiation.

bioRxiv · Apr 11, 2023Cancer Biology

Deciphering TP53 mutant Cancer Evolution with Single-Cell Multi-Omics

A. Rodriguez-Meira, R. Norfo, W. X. Wen, A. L. Chedeville, H. Rahman, J. OSullivan, G. Wang, E. Louka, W. Kretzschmar, A. Paterson, C. Brierley, J.-E. Martin, C. Demeule, M. Bashton, N. Sousos, , A. J. Mead

The paper uses single-cell multi-omic analysis to study TP53-mutant cancer evolution in leukaemia, identifying a role for chronic inflammation in promoting TP53 mutant clones.

bioRxiv · Mar 28, 2022 · PreprintCancer Biology

Single cell genotyping of matched bone marrow and peripheral blood cells in treatment naive and AZA-treated MDS and CMML

A. Schnegg-Kaufmann, J. A. I. Thoms, G. S. Bhuyan, H. R. Hampton, L. Vaughan, K. Rutherford, P. M. Kakadia, E. M. V. Johansson, T. Failes, G. M. Arndt, J. Koval, R. Lindeman, P. Warbuton, A. Rodriguez-Meira, A. J. Mead, , J. E. Pimanda

This study examines the contribution of mutated hematopoietic stem and progenitor cells to blood cell populations in MDS and CMML before and after AZA treatment.

bioRxiv · Jan 20, 2022 · PreprintCancer Biology

A novel human fetal liver-derived model reveals that MLL-AF4 drives a distinct fetal gene expression program in infant ALL

S. Rice, T. Jackson, N. T. Crump, N. Fordham, N. Elliott, S. O Byrne, S. Inglott, D. Ladon, G. Wright, J. Bartram, P. Ancliff, A. J. Mead, C. Halsey, I. Roberts, T. A. Milne, A. Roy

bioRxiv · Nov 15, 2020 · PreprintCancer Biology

Single-cell analyses reveal aberrant pathways for megakaryocyte-biased hematopoiesis in myelofibrosis and identify mutant clone-specific targets

B. Psaila, G. Wang, A. Rodriguez Meira, E. F. Heuston, R. Li, J. O'Sullivan, N. Sousos, S. Anderson, Y. Senis, O. Weinberg, M. L. Callicchio, NIH Intramural Sequencing Core, D. Iskander, D. Royston, D. Milojkovic, , A. J. Mead

The paper uses single-cell multi-omics to identify aberrant megakaryocyte pathways in myelofibrosis and discovers JAK2-mutant-specific targets for immunotherapy.

bioRxiv · May 20, 2019Cancer Biology