Author

D. S. Cafiso

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 3 Organism:E. coli· 2 Research Focus:host-pathogen & immune response· 2 Approach:deep learning· 1 Assay:electronic health records· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

D. A. Nyenhuis· 2 shared T. D. Nilaweera· 2 shared B. Her· 1 shared J. M. Hays· 1 shared P. M. Kasson· 1 shared R. Nakamoto· 1 shared S. B. Nyenhuis· 1 shared S. Katti· 1 shared

Activity by Year

2019-2021 · peak 3/yr

Co-Author Collaboration Network

9 top collaborators · 10 mutual co-author links

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2 shared papersBiophysics

D. A. Nyenhuis

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4 papers

Recent·Most cited

Structural intermediates observed only in intact Escherichia coli indicate a mechanism for TonB-dependent transport

T. D. Nilaweera, D. A. Nyenhuis, D. S. Cafiso

The paper uses pulse EPR to study BtuB in intact E. coli, showing substrate binding induces structural changes regulated by TonB, not observed in reconstituted systems.

bioRxiv · Mar 18, 2021Biophysics

Partial metal ion saturation of C2 domains primes Syt1-membrane interactions

S. Katti, S. B. Nyenhuis, B. Her, D. S. Cafiso, T. I. Igumenova

This study shows that partial metal ion saturation of Syt1's C2 domains primes its membrane interactions by restricting conformational plasticity and positioning for full activation.

bioRxiv · Oct 18, 2019Biochemistry

Disulfide chaperone knock-outs enable in-vivo double spin-labeling of an outer-membrane transporter

D. S. Cafiso, T. D. Nilaweera, D. A. Nyenhuis, R. Nakamoto

The paper shows that disulfide bond formation in E. coli prevents double spin-labeling of BtuB cysteines, but dsbA/B null mutants enable this labeling and reveal structural differences in vivo.

bioRxiv · Jul 22, 2019Biophysics

Hybrid refinement of heterogeneous conformational ensembles using spectroscopic data

J. M. Hays, D. S. Cafiso, P. M. Kasson

This study develops a method to refine heterogeneous conformational ensembles using spectroscopic data, showing improved accuracy in capturing conformational states of syntaxin-1a.

bioRxiv · May 31, 2019Biophysics