Author

T. I. Igumenova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:protein folding & dynamics· 4 Assay:protein structure· 3 Research Focus:drug response / drug discovery· 2 Assay:structural biology· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Organism:E. coli· 1

Frequent Co-Authors

S. Katti· 3 shared S. S. Katti· 3 shared B. Her· 2 shared A. B. Taylor· 1 shared A. H. Nile· 1 shared A. K. Srivastava· 1 shared A. Tripathi· 1 shared D. S. Cafiso· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersBiochemistry

S. Katti

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Protein-Cadmium Interactions in Crowded Biomolecular Environments Probed by In-celland Lysate NMR Spectroscopy

S. S. Katti, T. I. Igumenova

This study uses in-cell and lysate NMR spectroscopy to investigate how cadmium interacts with protein targets in crowded environments, revealing its ability to replace zinc in structural sites and its potential for bioremediation.

bioRxiv · Nov 3, 2023 · PreprintBiophysics

A novel bivalent interaction mode underlies a non-catalytic mechanism for Pin1-mediated Protein Kinase C regulation

X.-R. Chen, K. Dixit, Y. Yang, M. I. McDermott, H. T. Imam, V. A. Bankaitis, T. I. Igumenova

This paper shows Pin1 regulates PKC through a non-catalytic mechanism by binding its C-terminal tail via a novel bivalent interaction mode.

bioRxiv · Sep 18, 2023Biophysics

Mechanisms by Which Small Molecule Inhibitors Arrest Sec14 Phosphatidylinositol Transfer Protein Activity

X. R. Chen, L. Poudel, Z. Hong, P. Johnen, S. S. Katti, A. Tripathi, A. H. Nile, S. M. Green, G. Schaaf, F. Bono, v. bankaitis, T. I. Igumenova

This study investigates how small molecule inhibitors affect Sec14 phosphatidylinositol transfer protein activity using structural analysis to inform antifungal drug design.

bioRxiv · Aug 1, 2022 · PreprintBiophysics

Structural anatomy of C1 domain interactions with DAG and other agonists

S. S. Katti, I. V. Krieger, J. Ann, J. Lee, J. C. Sacchettini, T. I. Igumenova

The paper reports high-resolution crystal structures of a C1 domain bound to DAG and agonists, revealing mechanisms of lipid recognition and guiding drug design.

bioRxiv · Sep 3, 2021 · PreprintBiophysics

Interference of pH buffer with Pb2+-peripheral domain interactions: obstacle or opportunity?

S. Katti, T. I. Igumenova

The paper shows that using Bis-Tris buffer helps identify high-affinity Pb2+ binding sites in Syt1's Ca2+-sensing domains, revealing differences in membrane-binding responses between C2A and C2B domains.

bioRxiv · Dec 31, 2019Biochemistry

Partial metal ion saturation of C2 domains primes Syt1-membrane interactions

S. Katti, S. B. Nyenhuis, B. Her, D. S. Cafiso, T. I. Igumenova

This study shows that partial metal ion saturation of Syt1's C2 domains primes its membrane interactions by restricting conformational plasticity and positioning for full activation.

bioRxiv · Oct 18, 2019Biochemistry

High affinity interactions of Pb2+ with Synaptotagmin I

S. Katti, B. Her, A. K. Srivastava, A. B. Taylor, S. W. Lockless, T. I. Igumenova

This study identifies two high-affinity Pb2+ binding sites in Synaptotagmin I and shows Pb2+ can act as a kinetic and thermodynamic trap, interfering with Ca2+-dependent function.

bioRxiv · Jun 16, 2018Biophysics